α2巨球蛋白在脑梗死后精神病性障碍患者脑脊液中的表达及临床意义  

Expression and clinical significance ofα2-macroglobulin in cerebrospinal fluid of schizophrenic patients after cerebral infarction

作　　者：寇建华 李涛 KOU Jianhua;LI Tao(Jian’an Hospital of Xuchang City,Xuchamg 461000,China)

机构地区：[1]河南省许昌市建安医院,河南许昌461000 [2]河南省许昌市中心医院,河南许昌461000

出　　处：《中风与神经疾病杂志》2020年第4期358-361,共4页Journal of Apoplexy and Nervous Diseases

摘　　要：目的探究α2巨球蛋白(α2MG)在脑梗死后精神病性障碍患者脑脊液中的表达及临床意义。方法选取本院2015年3月-2019年3月脑部疾病所致精神病性障碍患者136例,其中脑梗死患者53例(脑梗精神病组),非脑梗死患者83例(非脑梗精神病组)。采用酶联免疫吸附(ELISA)法检测两组患者脑脊液中α2MG、白细胞介素6(IL-6)、C反应蛋白(CRP)、免疫球蛋白M(IgM)、补体C3水平,并分析α2MG与IL-6、CRP、IgM、C3相关性;绘制受试者工作特征(ROC)曲线分析血清α2MG水平对脑梗死后精神病性障碍的诊断价值。结果与非脑梗精神病组相比,脑梗精神病组患者脑脊液中α2MG、IL-6、CRP、C3、IgM水平较高(P<0.05)。Pearson分析显示脑梗精神病组患者脑脊液中α2MG水平与IL-6、CRP、C3、IgM水平均呈正相关(r=0.413,P=0.002;r=0.553,P=0.000;r=0.613,P=0.000;r=0.512,P=0.000)。ROC曲线结果显示,脑脊液中α2MG水平对脑梗死后精神病性障碍诊断的曲线下面积为0.897,截断值1.968μg/ml,灵敏度为83.0%,特异度为94.0%,95%CI为0.828~0.967。结论α2MG在脑梗死后精神病性障碍患者脑脊液中水平上升,对脑梗死后易发生精神病性障碍具有一定临床意义。Objective To investigate the expression and clinical significance ofα2-macroglobulin(α2MG)in cerebrospinal fluid of schizophrenia patients after cerebral infarction.Methods One hundred and thirty-six psychotic disorder patients were selected from March 2015 to March 2019,including 53 patients with traumatic cerebral infarction(cerebral infarction group)and 83 patients with non-cerebral infarction(non cerebral infarction group).The levels ofα2MG,interleukin-6(IL-6),C-reactive protein(CRP),immunoglobulin M(IgM)and complement C3 were detected by enzyme-linked immunosorbent assay(ELISA),the correlations betweenα2MG and IL-6,CRP,IgM,C3 were analyzed;and the ROC curve was drawn to analyze the diagnostic value of serumα2MG level in schizophrenia after cerebral infarction.Results The levels ofα2MG,IL-6,CRP,C3 and IgM in cerebrospinal fluid of patients in cerebral infarction group were higher than those of patients in non-cerebral infarction group(P<0.05).Pearson analysis showed that the levels ofα2MG in cerebrospinal fluid were positively correlated with the levels of IL-6,CRP,C3 and IgM(r=0.413,P=0.002;r=0.553,P=0.000;r=0.613,P=0.000;r=0.512,P=0.000).ROC curve showed that the area under the curve ofα2MG level in cerebrospinal fluid for the diagnosis of psychotic disorder after cerebral infarction was 0.897,the cutoff value was 1.968μg/ml,the sensitivity was 83.0%,the specificity was 94.0%,and the 95%CI was 0.828~0.967.Conclusion The levels ofα2MG in cerebrospinal fluid of psychotic disorder patients after cerebral infarction rises,which has certain clinical significance for the diagnosis of cerebral infarction psychotic disorder.

关 键 词：Α2巨球蛋白 脑梗死 精神病性障碍 脑脊液 临床意义 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R749[医药卫生—临床医学]