红参发酵产物联合长春瑞滨及顺铂化疗方案治疗晚期非小细胞肺癌患者的疗效  

The effect of combination therapy of fermented red ginseng extract plus vinorelbine and cisplatin chemotherapy in patients with advanced non-small cell lung cancer

作　　者：韩文杰[1] 刘军[1] 孙永臣[1] HAN Wenjie;LIU Jun;SUN Yongchen(Department of Oncology,the First People’s Hospital of Shangqiu,Shangqiu 476100,He’nan,China)

机构地区：[1]商丘市第一人民医院肿瘤科,河南商丘4761000

出　　处：《癌症进展》2020年第7期694-698,共5页Oncology Progress

摘　　要：目的探讨红参发酵产物联合长春瑞滨及顺铂化疗方案治疗晚期非小细胞肺癌患者的疗效。方法将104例晚期非小细胞肺癌患者随机分为治疗组及对照组,每组52例。对照组患者给予单纯长春瑞滨^+顺铂化疗方案,治疗组患者在对照组基础上联合应用红参发酵产物。分别在治疗前后采用疲劳症状量表(FSI)、肺癌治疗功能评价量表(FACT-L)评价两组患者疲劳症状及生活质量,并比较治疗前后两组患者血清肿瘤标志物水平、免疫功能指标水平、药物不良反应及生存情况。结果治疗前,两组患者FSI各维度评分及总分,FACT-L各维度评分及总分,细胞角质蛋白19片段抗原21-1(CYFRA21-1)、神经元特异性烯醇化酶(NSE)、癌胚抗原(CEA)、自然杀伤(NK)细胞、CD3^+、CD4^+、CD8^+、CD4^+/CD8^+水平比较,差异均无统计学意义(P﹥0.05)。治疗后,对照组患者FSI各维度评分及总分均高于治疗前及治疗组;治疗组患者生理状态、情绪状态、对疾病关注度评分及总分均高于治疗前,且生理状态、社会家庭状态、情绪状态、功能状态、对疾病关注度评分及总分均高于对照组;两组患者CEA、CYFRA21-1及NSE水平均较治疗前下降,且治疗组患者均低于对照组患者;治疗组患者NK细胞、CD3^+、CD4^+及CD4^+/CD8^+水平均较治疗前上升,且均高于对照组患者,差异均有统计学意义(P﹤0.05)。治疗组患者血液学不良反应发生例数少于对照组,差异有统计学意义(P﹤0.05)。结论红参发酵产物联合长春瑞滨及顺铂化疗方案能够有效提高晚期非小细胞肺癌患者的免疫功能及生活质量,降低血清肿瘤标志物水平,并减轻血液学不良反应。Objective To explore the effect of combination therapy comprising fermented red ginseng extract plus vinorelbine and cisplatin chemotherapy in patients with advanced non-small cell lung cancer(NSCLC).Method A total of 104 cases of advanced NSCLC were included and randomizedas study group or control group,with 52 cases in each.Patients in control group received vinorelbine and cisplatin chemotherapy alone,while those in study group were administered with combination therapy of additional fermented red ginseng extract plus vinorelbine and cisplatin.The fatigue symptoms inventory(FSI),and functional assessment of cancer therapy-lung(FACT-L)scale were used to assess the severity of fatigue and quality of life of all patients before and after treatment,respectively;in addition,the tumor marker levels,immune function indexes,occurrence of adverse drug reactions and survival of the two groups before and after treatment were compared.Result The subscale score and total score of FSI and FACT-L,levels of cytokeratin 19 fragment antigen 21-1(CYFRA21-1),neuron specific enolase(NSE)and carcinoembryonic antigen(CEA),natural killer(NK)cell,CD3^+,CD4^+,CD8^+,and CD4^+/CD8^+were similar between the two groups before treatment(P>0.05).After treatment,the subscale score and total score of FSI in control group were higher than that before treatment and than in study group;moreover,the scores concerning domains of physiological,emotional,cognitive and total score in study group were improved,with notable higher scores with regard to physical,social/family,emotional,functional well-being,cognitive and total score compared to control group;CEA,CYFRA21-1 and NSE were decreased in both groups after treatment,and greater reduction observed in study group than in control group;NK cells,CD3^+,CD4^+and CD4^+/CD8^+ levels were also improved after treatment in study group,and all were significantly higher compared to control group(P<0.05).Less hematological toxicities were recorded in study group compared to control group(P<0.05).Conclusion Fe

关 键 词：红参发酵产物 顺铂 长春瑞滨 晚期非小细胞肺癌 

分 类 号：R734.2[医药卫生—肿瘤]