达菲林联合丹莪妇康煎膏对子宫内膜异位症患者血清COX-2、Flk-1和炎性因子水平影响  

The influence of diphereline combined with Danqi fukang oral paste for treating women with endometriosis on their levels of serum COX-2 Flk-1 and inflammatory factors

作　　者：李小芳 赵玉华 LI Xiaofang;ZHAO Yuhua(Miyun Teaching Hospital, Capital Medical University, Beijing, 101500)

机构地区：[1]首都医科大学密云教学医院,101500

出　　处：《中国计划生育学杂志》2020年第3期324-327,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨达菲林联合丹莪妇康煎膏对子宫内膜异位症患者血清COX-2 Flk-1和炎性因子水平影响。方法:纳入本院2016年3月-2018年3月收治的子宫内膜异位症患者100例,按数字表法分为观察组(50例)及对照组(50例),对照组予以达菲林治疗,观察组给予达菲林联合丹莪妇康煎膏治疗,观察两组临床疗效、血清COX-2、Flk-1水平、炎性因子水平、疼痛VAS评分及不良反应。结果:观察组治疗有效率(94.0%)高于对照组(66.0%),血清COX-2、Flk-1、IL-6、IL-8水平均低于对照组,治疗后VAS评分[第5天(4.3±1.4分)、20天(1.1±1.2分)、60天(0.6±0.2)分]均低于对照组[(7.0±1.3分、7.0±1.3分、7.0±1.3分)],不良反应发生率(12.0%)低于对照组(32.2%)(均P<0.05)。结论:达菲林联合丹莪妇康煎膏治疗子宫内膜异位症患者提高了治疗效果,降低例血清COX-2 Flk-1和炎性因子水平,不良反应降低。Objective:To investigate the influence of diphereline combined with Danqi fukang oral paste for treating women with endometriosis on their levels of serum COX-2 Flk-1 and inflammatory factors.Methods:100 women with endometriosis were randomly divided into contral group and study group(50 cases in each group)by the digital table method from March 2016 to March 2018.The women in the control group were treated by diphereline,and the women in the study group were treated by diphereline combined with Danshen fukang oral paste.The clinical efficacy,the levels of serum COX-2,Flk-1 and inflammatory factor,VAS pain score,and the rate of adverse reaction of women in the two groups were observed.Results:The effective rate of women in the study group was 94.0%,which was significant higher than that(66.0%)of women in the control group,but the serum levels of cox-2,flk-1,il-6 and il-8 of women in the study group were significant lower.After treatment,the VAS scores of women on the fifth day,the 20th day,and the 60th day were 4.3±1.4 points,1.1±1.2 points,and 0.6±0.2 points,respectively,which were significant lower than those(7.0±1.3 points,7.0±1.3 points,and 7.0±1.3 points,respectively)of women in the control group.The incidence of adverse reactions of women in the study group was 12.0%,which was significant lower than that(32.2%)of women in the control group(P<0.05).Conclusion:Diphereline combined with Danqi fukang oral paste for treating women with endometriosis can significantly increase the efficacy,and can reduce the levels of serum COX-2,Flk-1 and inflammatory factor,and the rate of adverse reaction.

关 键 词：子宫内膜异位症 达菲林 丹莪妇康煎膏 COX-2 FLK-1 炎性因子 

分 类 号：R73[医药卫生—肿瘤]