早期复发性流产患者病因及流产胚胎染色体异常分析  

Routine Causes of early recurrent spontaneous abortion of women and the chromosomal abnormalities of its aborted embryos

作　　者：王东霞 武艳琪 刘俊杰 WANG Dongxia;WU Yanqi;LIU Junjie(Zhoukou Maternal and Child Health Care Hospital(Zhoukou Children's Hospital), Henan Province, 466000)

机构地区：[1]河南省周口市妇幼保健院(周口市儿童医院),466000

出　　处：《中国计划生育学杂志》2020年第3期404-407,共4页Chinese Journal of Family Planning

摘　　要：目的:分析早期复发性流产患者病因及流产胚胎染色体异常检出情况。方法:选取本院接诊的104例早期复发性流产患者临床资料,均行盆腔B超、宫腔镜及胚胎染色体检查,分析病因构成及胚胎异常染色体核型分布。结果:患者流产病因包括夫妻染色体异常(7.7%)、子宫异常(8.8%)、内分泌异常(13.7%)和流产胚胎染色体异常(59.8%)。流产≥3次组年龄高于流产2次组(P<0.05),而体质指数、夫妻染色体异常、子宫异常、内分泌异常等不同流产次组间无差异(P>0.05),流产胚胎染色体异常率流产2次组高于流产≥3次组(P<0.05)。流产胚胎的染色体检测110例次,核型异常68例次(61.8%),包括非整倍体53例次、多倍体5例次、其他染色体异常10例次。非整倍体中以16-三体(19.1%)、22-三体(10.3%)、X单体最为多见(10.3%)。结论:早期复发性流产患者胚胎染色体异常率较高,应作为常规筛查病因,并将复发性流产病因筛查提前至自然流产2次更为合理。Objective:To analyze the routine causes of early recurrent spontaneous abortion of women,and to study the chromosomal abnormalities of its aborted embryos.Methods:The clinical data of 104 women with early recurrent spontaneous abortion were analyzed retrospectively.All included women underwent pelvic B ultrasonography,hysteroscopy,and embryo chromosome examination.The etiology of early recurrent spontaneous abortion and the abnormal karyotype distribution of embryos of women were analyzed.Results:The causes of miscarriage included chromosomal abnormalities of the husband and wife(7.7%),uterine abnormalities(8.8%),endocrine abnormalities of women(13.7%),and chromosomal abnormalities of the aborted embryo(59.8%).The age of women with≥3 times abortion was significant higher than that of women with 2 times abortion(P<0.05),while there was no different in body mass index of women,rate of chromosomal abnormality of the husband and wife,and rates of uterine and endocrine abnormality between women with≥3 times abortion and women with 2 times abortion(P>0.05).The chromosomal abnormality rate of embryos of women with 2 times abortion was significant higher than that of women with≥3 times abortion(P<0.05).68(61.8%)in 110 aborted embryos after chromosome detection had karyotype abnormalities,which included 53 cases with aneuploidy of chromosome,5 cases with polyploidy of chromosome,and 10 cases with other chromosomal abnormalities.In the aborted embryos with aneuploidy of chromosome,16-trisomy(19.1%),22-trisomy(10.3%)and X monomer(10.3%)were the first three types of chromosomal abnormalities.Conclusion:The rate of embryo chromosome abnormalities of women with early recurrent spontaneous abortion are high,which should be screened as a common cause of recurrent abortion,and it is more reasonable to screen the etiology of women after two times spontaneous abortions.

关 键 词：早期复发性流产 胚胎染色体 染色体异常 病因筛查 

分 类 号：R714.21[医药卫生—妇产科学]