NCF4基因rs4821544T/C多态性与炎症性肠病关联性meta分析  

Association between neutrophil cytoplasmic factor 4 rs4821544T/C polymorphism and inflammatory bowel disease risk in Caucasian population:a meta-analysis

作　　者：吴鹏波[1,2] 饶倩 俞媛洁 柴红[1,2] 张国 郭一天[1,2] 谭诗云 WU Pengbo;RAO Qian;YU Yuanjie;CHAI Hong;ZHANG Guo;GUO Yitian;TAN Shiyun(Department of Gastroenterology,Renmin Hospital of Wuhan University,Wuhan,Hubei 430060,China;Hubei Key Laboratory of Digestive Diseases,Wuhan,Hubei 430060,China;Department of Gastroenterology,People′s Hospital of Guangxi Zhuang Autonomous Region,Nanning,Guangxi 530000,China)

机构地区：[1]武汉大学人民医院消化内科,湖北武汉430060 [2]消化系疾病湖北省重点实验室,湖北武汉430060 [3]广西壮族自治区人民医院消化内科,广西南宁530000

出　　处：《国际检验医学杂志》2020年第9期1074-1077,共4页International Journal of Laboratory Medicine

基　　金：湖北省自然科学基金项目(2018CFB236)。

摘　　要：目的研究高加索人群嗜中性粒细胞胞浆因子4(NCF4)基因rs4821544T/C多态性与炎症性肠病的相关性。方法全面检索关于NCF4基因rs4821544T/C多态性与炎症性肠病关联性的病例对照研究,纳入符合条件的研究,并进行数据合并。利用rs4821544T/C不同的遗传模型比值比(OR)及其95%CI作为效应指标进行分析。结果共15个病例对照研究纳入22317例对象,其中克罗恩病患者8155例,溃疡性结肠炎患者3257例,健康对照10905例。Meta分析结果表明,rs4821544T/C多态性与克罗恩病易感性的相关性有统计学意义[CC vs.TT:OR(95%CI)=1.38(1.17~1.51),P=0.000;CC/TC vs.TT:OR(95%CI)=1.11(1.05~1.21),P=0.039;CC vs.TC/TT:OR(95%CI)=1.30(1.13~1.47),P=0.000)]。而rs4821544T/C多态性与溃疡性结肠炎易感性的相关性无统计学意义[CC vs.TT:OR(95%CI)=1.11(0.90~1.36),P=0.296;TC vs.TT:OR=1.04(0.94~1.14),P=0.441;CC/TC vs.TT:OR(95%CI)=1.04(0.95~1.18),P=0.381;CC vs.TC/TT:OR(95%CI)=1.06(0.90~1.24),P=0.429]。结论高加索人群克罗恩病易感性与NCF4基因rs4821544T/C多态性有关,而溃疡性结肠炎与该基因多态性无关。Objective To investigate the associations between neutrophil cytoplasmic factor 4(NCF4)rs4821544T/C polymorphism and inflammatory bowel disease(IBD)risk in Caucasian population.Methods Case-control studies on the associations between the NCF4 rs4821544T/C polymorphism and IBD were comprehensively searched.All the related studies were further strictly selected according to the inclusion criteria.odds ratios(OR)with 95%CI were used to assess the associations between rs4821544T/C polymorphism and IBD risk in Caucasian population.Results A total of 22317 subjects were included in 15 case-control studies,including 8155 patients with Crohn′s disease,3257 patients with ulcerative colitis and 10905 healthy controls.The results of meta-analysis showed that rs4821544t/C polymorphism was significantly associated with Crohn′s disease susceptibility[CC vs.TT:OR(95%CI)=1.38(1.17-1.51),P=0.000;CC/TC vs.TT:OR(95%CI)=1.11(1.05-1.21),P=0.039;CC vs.TC/TT:OR(95%CI)=1.30(1.13-1.47),P=0.000)].However,rs4821544T/C polymorphism and susceptibility to ulcerative colitis were not statistically significant[CC vs.TT:OR(95%CI)=1.11(0.90-1.36),P=0.296;TC vs.TT:OR=1.04(0.94-1.14),P=0.441;CC/TC vs.TT:OR(95%CI)=1.04(0.95-1.18),P=0.381;CC vs.TC/TT:OR(95%CI)=1.06(0.90-1.24),P=0.429].Conclusion The susceptibility of Crohn′s disease in Caucasian population is related to NCF4 rs4821544T/C polymorphism,while ulcerative colitis is not related to this gene polymorphism.

关 键 词：嗜中性粒细胞胞浆因子4 基因多态性 炎症性肠病 META分析 

分 类 号：R574[医药卫生—消化系统] R446.1[医药卫生—内科学]