血清IL-18及S100P水平对2型糖尿病合并急性后循环脑梗死的相关性研究  

Study on the relationship between the levels of IL-18 and S100P in type 2 diabetes mellitus patients with acute posterior circulation cerebral infarction

作　　者：苗同云 王刚 马凯 金学林 MIAO Tongyun;WANG Gang;MA Kai;JIN XueLin(Department of Neurology,Shizuishan Central Hospital,The Fifth People's Hospital of Ningxia,Shizuishan 753200,China;Department of Emergency,Shizuishan Central Hospital,The Fifth People's Hospital of Ningxia,Shizuishan 753200,China;Ningxia Medical University,Yinchuan 750004,China;Department of Internal Medicine,Lingzhou Hospital,Lingwu 751400,China)

机构地区：[1]宁夏第五人民医院石嘴山中心医院神经内科门诊,宁夏石嘴山753200 [2]宁夏第五人民医院石嘴山中心医院急诊科,宁夏石嘴山753200 [3]宁夏医科大学,宁夏银川7500004 [4]宁夏灵武市灵州医院内科,宁夏银川751400

出　　处：《宁夏医学杂志》2020年第2期126-128,共3页Ningxia Medical Journal

基　　金：宁夏自然科学基金资助项目(NZ16241)。

摘　　要：目的探讨血清白细胞介素-18(IL-18)及S100P与2型糖尿病合并急性后循环脑梗死疾病的关系。方法选择366例急性后循环脑梗死患者为研究对象,其中144例为2型糖尿病合并急性后循环脑梗死,138例为单纯性急性后循环脑梗死非2型糖尿病,另外选择84例单纯性糖尿病患者作为对照研究。比较2型糖尿病合并急性后循环脑梗死组与非2型糖尿病合并急性后循环脑梗死组患者IL-18及S100P的变化水平。结果急性后循环脑梗死组IL-18为(94.56±15.55)pmol/mL,高于单纯性糖尿病组的(64.55±4.34)pmol/mL(P<0.05);急性后循环脑梗死组S100P为(10.672±1.976)ng/L,高于单纯性糖尿病组的(3.933±0.406)ng/L(P<0.05)。进一步研究发现,2型糖尿病合并急性后循环脑梗死组IL-18为(106.967±7.545) pmol/mL,高于单纯性急性后循环脑梗死组的(78.791±5.438)pmol/mL水平(P<0.05);2型糖尿病合并急性后循环脑梗死组S100P为(12.310±0.669)ng/L,高于单纯性急性后循环脑梗死组的(8.589±0.699)ng/L水平(P<0.05)。结论血清IL-18及S100P对2型糖尿病合并急性后循环脑梗死疾病患者发病中具有重要作用。Objective To explore the relationship between the level of IL-18 and S100 P in type 2 diabetes mellitus patients with acute posterior circulation cerebral infarction.Methods 366 patients with acute posterior circulation cerebral infarction were selected,144 cases of them were type 2 diabetes patients with acute posterior circulation cerebral infarction and 138 cases of them were non type 2 diabetes patients with acute posterior circulation cerebral infarction and 84 patients with simple type 2 diabetes were selected as the control group. The levels of IL-18 and S100 P were measured by using ELISA methods. The levels of IL-18 and S100 P protein in the three groups were compared.Results The level of IL-18 in patients with acute posterior circulation cerebral infarction(94.56±15.55)pmol/mL was higher than that in the control group(64.55±4.34)pmol/mL(P<0.05). The level of S100 P in patients with acute posterior circulation cerebral infarction(10.672±1.976)ng/L were higher than those in the control group(3.933±0.406)ng/L(P<0.05). Further study showed that the level of IL-18 was(106.967±7.545) pmol/mL in the type 2 diabetes patients with acute posterior circulation cerebral infarction,which was higher than that(78.791±5.438)pmol/ml in the non-type 2 diabetes patients with acute posterior circulation cerebral infarction(P<0.05). The level of S100 P was(12.310±0.669)(106.967±7.545)ng/L in the type 2 diabetes patients with acute posterior circulation cerebral infarction,which was higher than that(8.589±0.699)ng/L in the non-type 2 diabetes patients with acute posterior circulation cerebral infarction(P<0.01).Conclusion IL-18 and S100 P may play an important role in the development of type 2 diabetes patients with acute posterior circulation cerebral infarction.

关 键 词：2型糖尿病 急性后循环脑梗死 白细胞介素-18 S100P蛋白 

分 类 号：R743.33[医药卫生—神经病学与精神病学]