鼻腔NK/T细胞淋巴瘤患者的生存及预后分析  

Survival and Prognosis of Patients with Nasal NK/T-Cell Lymphoma

作　　者：谢丹娜 李英华 陈晓静 卢思敏 胡腾 韩云炜 XIE Dan-Na;LI Ying-Hua;CHEN Xiao-Jing;LU Si-Min;HU Teng;HAN Yun-Wei(Department of Oncology,The Affiliated Hospital of Southwest Medical University,Luzhou 646000,Sichuan Province,China)

机构地区：[1]西南医科大学附属医院肿瘤科,四川泸州646000

出　　处：《中国实验血液学杂志》2020年第2期507-511,共5页Journal of Experimental Hematology

摘　　要：目的:分析鼻腔结外NK/T细胞淋巴瘤(extranodal natural killer/T-cell lymphoma,ENKL)患者的生存及预后状况。方法:选取2012年6月-2018年6月本院初治鼻腔ENKL患者52例。分别采用Kaplan-Meier法、COX比例风险模型对各个因素和预后的关系作单因素及多因素分析。结果:患者中位OS时间为72个月。单因素分析表明,性别、年龄、IPI、ECOG、Hb、临床分期及治疗模式均与鼻腔ENKL患者的OS相关。多因素分析显示,Hb、年龄及临床分期是影响鼻腔ENKL患者OS的独立因素。结论:Hb、年龄及临床分期可用于预测鼻腔ENKL患者的预后。Objective:To analyze the survival and prognosis of patients with nasal extranodal natural killer/T-cell lymphoma(ENKL).Methods:The clinical data of newly diagnosed 52 patients with nasal NK/T-cell lymphoma from June 2012 to June 2018 were selected.Univariate and multivariate analysis was performed on the relationship between different clinical factors and prognosis by Kaplan-Meier method and COX proportional hazard model.Results:The median overall survival(OS)time of patients was 72 months.Univariate analysis showed that age,sex,IPI score,ECOG score,hemoglobin(Hb)level,clinical stage,and treatment pattern all associated with OS of nasal NK/T-cell lymphoma patients.Multivariate analysis showed that hemoglobin level,age and clinical stage were independent factors affecting OS of nasal NK/T lymphoma patients.Conclusion:Hemoglobin level,age and clinical stage can be used as indicators to evaluate the prognosis of nasal NK/T-cell lymphoma.

关 键 词：鼻腔NK/T细胞淋巴瘤 临床因素 生存率 预后 

分 类 号：R733.1[医药卫生—肿瘤]