微卫星不稳定性在胃癌预后及疗效预测中的意义  

Significance of microsatellite instability for the prognosis and efficacy prediction in gastric cancer

作　　者：孟令桦 吴海涛[1] 梁婷婷[1] 王畅[1] Meng Linghua;Wu Haitao;Liang Tingting;Wang Chang(Cancer Center of the First Hospital of Jilin University,Changchun 130021,China)

机构地区：[1]吉林大学第一医院肿瘤中心,长春130021

出　　处：《肿瘤研究与临床》2020年第3期213-216,共4页Cancer Research and Clinic

摘　　要：微卫星不稳定性(MSI)是由DNA错配修复(MMR)蛋白功能缺陷导致,与多种肿瘤发生发展、预后及疗效预测密切相关。微卫星高度不稳定(MSI-H)与错配修复蛋白缺乏(dMMR)可能是胃癌患者预后良好的预测因素,也可能是可切除胃癌化疗疗效的负性预测因素;同时MSI-H/dMMR是晚期胃癌免疫检查点抑制剂有效治疗的预测标志物,但对于晚期胃癌姑息化疗的预测作用尚未明确。文章就MSI/MMR状态与胃癌预后及疗效预测方面的相关性研究进展进行阐述。Microsatellite instability(MSI)is caused by the deficiency of DNA mismatch repair(MMR)protein,which is closely related to the occurrence,development,prognosis and efficacy prediction of various tumors.MSI-high(MSI-H)and mismatch repair protein deficiency(dMMR)might be a predictor factor for the good prognosis of patients with gastric cancer,and a negative predictor factor for the chemotherapy efficacy of resectable gastric cancer.MSI-H/dMMR can be used as a marker for predicting the effective treatment outcome of immune checkpoint inhibitors in advanced gastric cancer,however,the predictive role in palliative chemotherapy of advanced gastric cancer is still unclear.This paper reviews the progress of the association of MSI/MMR with prognosis and efficacy prediction in gastric cancer.

关 键 词：胃肿瘤 微卫星不稳定性 错配修复蛋白 预后 疗效预测 

分 类 号：R735[医药卫生—肿瘤]