新型喹唑啉类化合物的合成研究  

Synthesis of Novel Quinazoline Compounds

作　　者：孟令强[1] 杨绍娟[2] 张小博[3] MENG Lingqiang;YANG Shaojuan;ZHANG Xiaobo(The Dean’s Office,Yanching Institute of Technology,Sanhe 065201,Hebei;School of Life and Health,Yanching Institute of Technology,Sanhe 065201,Hebei;College of Engineering,Yanching Institute of Technology,Sanhe 065201,Hebei)

机构地区：[1]燕京理工学院教务处,河北三河065201 [2]燕京理工学院生命与健康学院,河北三河065201 [3]燕京理工学院工学院,河北三河065201

出　　处：《四川师范大学学报（自然科学版）》2020年第3期357-363,共7页Journal of Sichuan Normal University（Natural Science）

基　　金：廊坊市科技支撑计划(2017011070)。

摘　　要：以2-氨基-4-甲氧基-3-(3-氯丙氧基)苯甲酸甲酯为原料,经环合、氯代和取代等反应得到6种新型喹唑啉类化合物,总收率为45%左右;目标产物结构经GC-MS和核磁~1HNMR进行表征.与传统方法相比,该法具有原料廉价易得、路线简短、操作简便和反应条件温和等优点,为后续的生物活性测试打下良好的基础.Six novel quinazolines were synthesized by the reaction of 2-amino-4-methoxy-3-( 3-chloropropoxy) benzoic acid methyl ester by cyclization,chlorination and substitution. The total yield was about 45%. The structure of target products was characterized by GC-MS and ~1HNMR. Compared with the traditional method,the method has the advantages of cheap raw materials,short route,easy operation and mild reaction conditions,which laid a good foundation for the subsequent bioactivity test.

关 键 词：2-氨基-4-甲氧基-3-(3-氯丙氧基)苯甲酸甲酯 合成 新型喹唑啉类化合物 

分 类 号：R914.5[医药卫生—药物化学]