全植入人工面神经恢复周围性面神经麻痹兔眼轮匝肌闭眼功能的实验研究  

Restoration of orbicularis oculi muscle function with totally implanted artificial facial nerve

作　　者：张奕[1] 刘景全[2] 张群峰 孙雅静 王宇娟[4] 许栋岳 金城[1] 李克勇[6] Zhang Yi;Liu Jingquan;Zhang Qunfeng;Sun Yajing;Wang Yujuan;Xu Dongyue;Jin Cheng;Li Keyong(Department of Otorhinolaryngology,Renji hospital,School of Medicine,Shanghai Jiaotong University,Shanghai 200127,China;Institute of Micro/Nano Science and Technology,Shanghai Jiaotong University,Shanghai 200240,China;Shanghai Nuocheng Electrical Co.,Ltd.Shanghai 200245,China;Department of Otorhinolaryngology Head and Neck Surgery,Shaanxi Provincial Peoples′Hospital,Xi′an 710068,China;Department of Otorhinolaryngology,Affiliated Hospital of Chifeng University,Chifeng 024050,China;Department of Otorhinolaryngology Head and Neck Surgery,Shanghai General Hospital of Shanghai Jiaotong University,Shanghai 200080,China)

机构地区：[1]上海交通大学医学院附属仁济医院耳鼻咽喉科,200127 [2]上海交通大学微纳电子学院,200240 [3]上海诺诚电气有限公司,200245 [4]陕西省人民医院耳鼻咽喉头颈外科,西安710068 [5]赤峰医学院附属医院耳鼻咽喉科,024050 [6]上海交通大学附属第一人民医院耳鼻咽喉头颈外科,200080

出　　处：《中华耳鼻咽喉头颈外科杂志》2020年第3期236-240,共5页Chinese Journal of Otorhinolaryngology Head and Neck Surgery

基　　金：国家自然科学基金面上项目(60876082、81070779);国家自然科学基金重点项目(5103500);上海市科委生物医药领域支撑项目(11441900102、14441902000)。

摘　　要：目的探讨全植入人工面神经恢复周围性面神经麻痹兔眼轮匝肌闭眼功能的效果。方法2018年1月至2019年5月,将人工面神经植入单侧周围性面神经麻痹兔体内,于术后第7、28天,监测患侧眼轮匝肌刺激闭合阈及患侧与健侧眼轮匝肌运动的同步性,并通过SPSS13.0软件进行t检验。结果人工面神经植入术后第7、28天,实验兔患侧眼轮匝肌的闭合阈差异无统计学意义(P值均>0.05)。在观察期间,刺激健侧眼睑20次诱发健侧闭眼,未发现健侧未动而患侧运动的情况;植入第7天和第28天,患侧与健侧同步运动的同步率在19/20~20/20,差异均无统计学意义(P值均>0.05)。结论人工面神经系统具备工作状态稳定、刺激运动效果同步性高的特点,能够较好地恢复周围性面神经麻痹动物的眼轮匝肌的闭眼功能。Objective To investigate the effect of the artificial facial nerve on the restoration of orbicularis oculi muscle function for unilateral peripheral facial paralysis in rabbit.Methods Artificial facial nerve was implanted into the rabbit with unilateral peripheral facial paralysis between January 2018 and May 2019.At different time points after operation,the affected orbicularis oculi muscles′stimulation closure threshold and the synchronism about the motion of the two sides of orbicularis oculi muscles were monitored.T test was used with SPSS 13.0 software.Results There was no significant difference in the closure threshold of the orbicularis oculi muscle on the 7th and 28th days after artificial facial nerve implantation(P>0.05).The synchronism of the normal side eye closing movement triggered the affected orbicular oculi muscle movement with the artificial facial nerve was up 19/20 to 20/20 at different times.Conclusions The artificial facial nerve system had the features of stable working condition and high synchronizing effect for stimulating movement.It could restore the closed eye function in animals with peripheral facial paralysis animals and had great clinical application prospects.

关 键 词：面神经 面神经麻痹 植入式电刺激器 

分 类 号：R77[医药卫生—眼科]