攀枝花地区400例不良孕产史遗传咨询者细胞遗传学分析  

Cytogenetic analysis of 400 genetic counselors with adverse pregnancy history in Panzhihua area

作　　者：胡艳梅[1] 张利军[2] HU Yan-mei;ZHANG Li-jun(Panzhihua City Maternal and Child Health Care Hospital of Sichuan Province,Reproductive Medicine Center,Panzhihua,Sichuan 617000;Panzhihua City Maternal and Child Health Care Hospital of Sichuan Province,Prenatal Diagnostic Laboratory,Panzhihua,Sichuan 617000)

机构地区：[1]四川省攀枝花市妇幼保健院,生殖医学中心,四川攀枝花617100 [2]四川省攀枝花市妇幼保健院,产前诊断实验室,四川攀枝花617100

出　　处：《中国优生与遗传杂志》2020年第1期40-42,59,共4页Chinese Journal of Birth Health & Heredity

摘　　要：目的对攀枝花地区400例不良孕产史患者行外周血染色体检查,分析攀枝花地区不良孕产史与患者外周血染色体异常的关系。方法按照便利抽样法选取2016年1月~2018月12月在我院诊治的不良孕产史遗传咨询者400例作为研究对象,抽取患者的外周血进行淋巴细胞培养,行染色体制片,采用常规G显带技术对染色体的核型进行分析。结果 400例不良孕产史患者共检出21例染色体异常核型,检出率为5.25%。其中,56例自然流产1次检出异常核型2例,检出率为0.5%;169例自然流产2次检出异常核型5例,检出率为1.25%;67例自然流产3次及以上检出异常核型8例,检出率为2%;32例生育畸形胎儿史检出异常核型1例,检出率为0.25%;46例男性不育检出异常核型3例,检出率为0.75%;30例女性原发不孕检出异常核型2例,检出率为0.5%。染色体异常核型中,4例相互易位,检出率为1%;1例罗伯逊易位,检出率为0.25%;16例多态改变,检出率为4%。自然流产1次、自然流产2次、自然流产3次及以上三组组间比较,差异有统计学意义(P<0.05)。结论染色体异常核型是导致患者发生不良孕产史的主要因素,因此对有不良孕产史的患者进行染色体核型分析,有利于临床医生对患者的病因进行诊断,为不良孕产进行治疗,减少畸形胎儿的出生率,对观测落实优生优育具有重要临床指导价值。Objective:To conduct a peripheral blood chromosome examination in 400 patients with adverse pregnancy history in Panzhihua area,and to analyze the relationship between the adverse pregnancy history of Panzhihua area and the peripheral blood chromosomal abnormalities of patients.Methods:According to the convenience sampling method,400 cases of genetic counselors with poor maternal history diagnosed in our hospital from January 2016 to December 2018 were selected as subjects.The peripheral blood of patients was taken for lymphocyte culture and chromosome preparation was adopted.Conventional G-banding techniques analyze the karyotype of chromosomes.Results:A total of 21 chromosomal abnormalities were detected in 400 patients with a history of adverse pregnancy.The detection rate was 5.25%.Among them,56 cases of spontaneous abortion were detected in 2 cases with abnormal karyotype,the detection rate was 0.5%;169 cases of spontaneous abortion were detected in 5 cases with abnormal karyotype,the detection rate was 1.25%;67 cases of spontaneous abortion 3 times 8 cases were detected with abnormal karyotype,the detection rate was 2%;32 cases of abnormal karyotype were detected in 32 cases of fetal malformation,the detection rate was 0.25%;46 cases of abnormal karyotype were detected in 46 cases of male infertility The detection rate was 0.75%;30 cases of abnormal karyotype were detected in 30 women with primary infertility,and the detection rate was 0.5%.Among the chromosomal abnormal karyotypes,4 cases were translocated,and the detection rate was 1%;1 case of Robertsonian translocation,the detection rate was 0.25%;16 cases of polymorphism changed,the detection rate was 4%.There were statistically significant differences between the three groups(1<,1 spontaneous abortion,2 spontaneous abortions,and above)(P<0.05).Conclusion:The abnormal karyotype of chromosomes is the main factor leading to the history of adverse pregnancy.Therefore,the karyotype analysis of patients with a history of adverse pregnancy is helpful for cli

关 键 词：攀枝花地区 不良孕产史 染色体异常 核型分析 

分 类 号：R714.21[医药卫生—妇产科学]