EB-DNA联合PET/CT诊断鼻咽癌患者复发的价值分析  

Value of EB-DNA Combined with PET/CT in the Diagnosis of Recurrence of Nasopharyngeal Carcinoma

作　　者：张野 赵蕊 王俊 ZHANG Ye;ZHAO Rui;WANG Jun(Department of Imaging,Fushun General Hospital of Liaoning Health Industry Group,Fushun 113008,Liaoning Province,China)

机构地区：[1]辽宁省健康产业集团抚矿总医院影像科,辽宁抚顺113008 [2]辽宁省抚顺市中心医院磁共振科,辽宁抚顺113008

出　　处：《中国CT和MRI杂志》2020年第5期82-84,132,共4页Chinese Journal of CT and MRI

基　　金：辽宁省自然科学基金资助项目(2013021045)。

摘　　要：目的探讨EB-DNA联合PET/CT诊断鼻咽癌复发的诊断价值。方法选择我院鼻咽癌复查患者165例,其中经病理活检确诊为复发患者58例,所有患者均于1周内实施EB-DNA检测、PET/CT检测及病理活检。观察EB-DNA检测、PET/CT检测分别及联合检查结果,并将其与病理活检进行一致性分析。结果共58例鼻咽癌复发患者,经血浆EB-DNA定量诊断复发42例(72.41%);经PET/CT检查诊断复发47例(81.03%);两者联合诊断复发55例(94.83%)。58例鼻咽癌复发患者,血浆EB-DNA定量检测、PET/CT检查结果与病理学结果存在一致性(Kappa值为0.4);两种诊断方式联合与病理学结果一致性较好(Kappa值为0.7)。经Pearson相关性分析:血浆EB-DNA定量检测与PET/CT检查结果呈正相关(r=0.874,P<0.05)。结论采用EB-DNA联合PET/CT的方法诊断鼻咽癌复发较单一诊断准确率更高。Objective To explore and analyze the combined diagnosis of EB-DNA combined with PET/CT in the recurrence of nasopharyngeal carcinoma.Methods A total of 165 patients with nasopharyngeal carcinoma in our hospital were selected.Among them,58 patients were diagnosed as recurrence by pathological biopsy.All patients were given EB-DNA detection,PET/CT detection and pathological biopsy within 1 week.The results of EB-DNA detection,PET/CT detection and combined test were observed,and they were given consistency analysis with pathological biopsy.Results Among the 58 patients with recurrent nasopharyngeal carcinoma,42 cases(72.41%)were with recurrence by plasma EB-DNA quantitative detection,and 47 cases(81.03%)were with recurrence by PET/CT.There were 55 cases(94.83%)of recurrence were diagnosed by combined detection.Among 58 patients with recurrent nasopharyngeal carcinoma,plasma EB-DNA quantitative detection and PET/CT findings were consistent with pathological results(Kappa value was 0.4).The combined results of the two diagnostic methods were consistent with the pathological results(Kappa value was 0.7).According to Pearson correlation analysis,plasma EB-DNA quantitative detection was positively correlated with PET/CT findings(r=0.874,P<0.05).Conclusion EB-DNA combined with PET/CT has higher accuracy rate than single detection in recurrent nasopharyngeal carcinoma.

关 键 词：鼻咽癌 复发 EB病毒DNA X线计算机体层摄影 正电子发射计算机断层显像 

分 类 号：R730.44[医药卫生—肿瘤] R739.6[医药卫生—临床医学]