脑血康胶囊联合抗血小板治疗缺血性脑卒中的效果及对脑血流量的影响  

Effect of Naoxuekang Capsule combined with anti-platelet therapy on ischemic stroke and its influence on cerebral blood flow

作　　者：陆翠燕 潘伟锋 邵妤 曹雯 LU Cuiyan;PAN Weifeng;SHAO Yu;CAO Wen(Department of Pharmacy,Putuo District Hospital of Traditional Chinese Medicine,Shanghai,200062;Pharmacy Department,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai,200437)

机构地区：[1]上海市普陀区中医医院药剂科,上海200062 [2]上海市中医药大学附属岳阳中西医结合医院药剂科,上海200437

出　　处：《实用临床医药杂志》2020年第3期40-43,47,共5页Journal of Clinical Medicine in Practice

基　　金：上海市科技厅科研项目(2015SZ010382)。

摘　　要：目的探讨脑血康胶囊联合抗血小板治疗缺血性脑卒中的效果及对脑血流量的影响。方法选取本院收治的533例缺血性脑卒中患者为研究对象,根据患者治疗方案分为3组,217例应用阿司匹林的患者纳入阿司匹林组,184例应用脑血康胶囊的患者纳入脑血康组,132例应用阿司匹林联合脑血康胶囊的患者纳入联合组。比较3组患者的临床疗效、美国国立卫生院卒中量表(NIHSS)评分、血小板聚集率、脑血流速度、脑血流量。结果联合组治疗总有效率为91.67%,显著高于阿司匹林组的82.95%以及脑血康组的80.98%(P<0.05)。治疗1、2、3个月时,联合组的NIHSS评分、血小板聚集率均低于阿司匹林组和脑血康组(P<0.05);联合组的平均脑血流速度、平均脑血流量均高于阿司匹林组和脑血康组(P<0.05)。阿司匹林组与脑血康组的治疗总有效率、NIHSS评分、血小板聚集率、脑血流速度、脑血流量比较无显著差异(P>0.05)。结论脑血康胶囊的抗血栓效果与阿司匹林相似,缺血性脑卒中患者联合使用脑血康胶囊和阿司匹林有利于改善神经功能,增加脑血流量,提高治疗效果。Objective To explore curative effect of Naoxuekang Capsule combined with anti-platelet therapy on ischemic stroke(IS)and its influence on cerebral blood flow(CBF).Methods A total of 533 IS patients who were admitted to the hospital were enrolled as study objects.According to different treatment plans,they were divided into three groups.A total of 217 patients treated with aspirin were included in aspirin group,184 patients treated with Naoxuekang Capsules were included in Naoxuekang group,and 132 patients treated with aspirin and Naoxuekang Capsules were included in combination group.The clinical curative effect,score of National Institutes of Health Stroke Scale(NIHSS),platelet aggregation rate,cerebral blood flow velocity and cerebral blood flow volume were compared among the three groups.Results The total response rate of treatment in combination group was 91.67%,which was significantly higher than 82.95%in aspirin group and 80.98%in Naoxuekang group(P<0.05).After 1-,2-and 3-month treatment,NIHSS score and platelet aggregation rate in combination group were lower than those in aspirin group and Naoxuekang group(P<0.05).The cerebral blood flow velocity and cerebral blood flow volume in combination group were higher than those in aspirin group and Naoxuekang group(P<0.05).There were no significant differences in total response rate of treatment,NIHSS score,platelet aggregation rate,cerebral blood flow velocity or cerebral blood flow volume between aspirin group and Naoxuekang group(P>0.05).Conclusion The antithrombotic effect of Naoxuekang Capsule is similar to that of aspirin.The combined application of Naoxuekang Capsule and aspirin in IS patients can improve nerve function,increase cerebral blood flow volume,and improve curative effect.

关 键 词：缺血性脑卒中 脑血康胶囊 阿司匹林 抗血小板 脑血流量 

分 类 号：R773.9[医药卫生—眼科]