老年急性脑出血并发癫痫患者血清HP,SOD,MDA水平表达及其与认知功能损害的相关性研究  

Study on the Correlation between Serum Haptoglobin, Superoxide Dismutase and Malondialdehyde in Elderly Patients with Epilepsy after Acute Cerebral Hemorrhage and Their Correlation with Cognitive Impairment

作　　者：王丽丽 张宁[2] 赵迎春 潘晓春 汪霞 左丽 WANG Li-li;ZHANG Ning;ZHAO Ying-chun;PAN Xiao-chun;WANG Xia;ZUO Li(Department of Neurology,Songjiang District Central Hospital in Shang hai,Shanghai 201609,China;Department of Neurosurgery,Southern Branch of the Sixth People’s Hospital Affiliated toShanghai Jiaotong University,Shanghai 201499,China)

机构地区：[1]上海松江区中心医院神经内科,上海201609 [2]上海交通大学附属第六人民医院南院神经外科,上海201499

出　　处：《现代检验医学杂志》2020年第2期108-111,共4页Journal of Modern Laboratory Medicine

基　　金：上海市卫生和计划生育委员会课题资助,编号201540141。

摘　　要：目的探讨老年急性脑出血并发癫痫患者血清触珠蛋白(haptoglobin,HP),超氧化物歧化酶(superoxide dismutase,SOD),丙二醛(malondialdehyde,MDA)的表达及其与认知损害的相关性。方法选择2018年1月~2019年5月上海松江区中心医院神经内科住院的老年急性脑出血病人383例,按照是否发生癫痫,将患者分为癫痫发作组(n=123)和癫痫未发作组(n=260)。比较两组患者一般临床资料及血清HP,SOD和MDA水平;采用蒙特利尔认知评估量表(MoCA)对患者的认知功能进行评价。Spearman分析MoCA评分和血清HP,SOD和MDA水平的相关性。结果与癫痫未发作组比较,癫痫发作组患者脑卒中史(25.20%vs 16.15%)、MoCA评分(22.76±2.41 vs 24.38±3.02),差异有统计学意义(χ^2=4.432, P <0.05;t=-5.214,P <0.01);发作组SOD(95.23±12.13 u/ml vs 100.91±12.95 u/ml)、HP(153.16±27.00mg/dl vs 166.06±28.69 mg/dl)均低于未发作组,差异有统计学意义(t=-4.089,-6.741,均P<0.01),而发作组MDA高于未发作组(10.87±3.32 nmol/ml vs8.69±2.48 nmol/ml),差异有统计学意义(t=7.174,P<0.01)。SOD与MoCA评分呈正相关(r=0.144, P=0.005),HP与MoCA评分呈显著正相关(r=0.114, P=0.026);而MDA与Mo CA评分呈负相关(r=-0.145,P=0.004)。结论老年急性脑出血并发癫痫患者血清SOD,MDA,HP的表达水平与认知功能损害的严重程度相关,有助于评估患者的病情和预后。Objective To investigate the expression of serum haptoglobin(HP), superoxide dismutase(SOD), malondialdehyde(MDA)and their correlation with cognitive impairment in elderly patients with acute cerebral hemorrhage and epilepsy. Methods 383 elderlypatients with acute cerebral hemorrhage from January 2018 to May 2019, in neurology department of Songjiang District Central Hospital in Shanghai were selected. According to whether epilepsy occurred, the patients were divided into epileptic attack group(n=123)and epileptic non attack group(n= 260). The general clinical data, serum HP, SOD and MDA levels of the two groups were compared, and the cognitive function of the patients was evaluated by the Montreal Cognitive Assessment Scale(MoCA). Spearman analyzed the correlation between MoCA score and serum HP, SOD, MDA levels. Results Compared with the epileptic group, the stroke history(25.20% vs 16.15%, χ^2=4.432,P<0.05), MoCA score(22.76 ± 2.41 vs 24.38 ± 3.02, t=-5.214, P < 0.01) and SOD(95.23±12.13 u/ml vs 100.91±12.95 u/ml), HP(153.16 ± 27.00 mg/dl vs 166.06 ± 28.69 mg/dl, P< 0.01) in the epileptic group were lower than those in the non epileptic group, the difference statistically significant(t=-4.089,-6.741,all P < 0.01),while MDA in the epileptic group was higher than that in the non epileptic group(10.8 ±3.32 nmol/ml vs 8.69±2.48 nmol/ml),the difference statistically significant(t=7.174, P< 0.01). SOD and MoCA scores was positively correlated(r=0.144, P< 0.05). HP and MoCA scores was positively correlated(r=0.114, P=0.026), MDA and MoCA scores were negatively correlated(r=-0.145, P=0.004). Conclusion The expression of SOD, MDA, HP in serum of the elderly patients with acute cerebral hemorrhagecomplicated with epilepsy is related to the severity of cognitive impairment, which is helpful to evaluate the condition and prognosis of the patients.

关 键 词：急性脑出血 癫痫 触珠蛋白 血清超氧化物岐化酶 丙二醛 认知损害 

分 类 号：R749.13[医药卫生—神经病学与精神病学] R446.11[医药卫生—临床医学]