盐酸米诺环素对种植体周围炎疗效的系统评价和Meta分析  

Efficacy of Minocycline Hydrochloride for Peri-implantitis:A Systematic Review and Meta-analysis

作　　者：高婷婷 黄姣[1] 张芷玮 白远亮 Gao Tingting;Huang Jiao;Zhang Zhiwei(Stomatological Hospital of Chongqing Medical University,Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences,Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education,Chongqing 401147,China)

机构地区：[1]重庆医科大学附属口腔医院牙周科,口腔疾病与生物医学重庆市重点实验室,重庆医科大学重庆市高校市级口腔生物医学工程重点实验室,重庆401147

出　　处：《华中科技大学学报（医学版）》2020年第1期89-94,共6页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

基　　金：重庆市高校市级口腔生物医学工程重点实验室资助项目(No.渝教科[2014]55号);2016年重庆高校创新团队建设计划资助项目(No.CXTDG201602006)。

摘　　要：目的系统评价去除菌斑生物膜后局部使用盐酸米诺环素对种植体周围炎的疗效,为盐酸米诺环素在种植体周围炎治疗中的作用提供循证医学证据。方法检索数据库:中国知网、万方、维普、中国生物医学文献数据库、PubMed和Cochrane Library等;检索时限:建库至2019年3月。由2位研究者独立地鉴别、分析、评估相关文献后使用Rev Man 5.3以及Stata 12.0进行数据分析。结果包含637个种植体的7个随机对照试验被最终纳入。Meta分析数据表明,盐酸米诺环素组与对照组探诊深度(PD)、出血指数(SBI)、菌斑指数(PI)的变化有差异[MD=-0.64,95%CI(-1.14,-0.14),P=0.01]、[MD=-2.12,95%CI(-3.09,-1.15),P<0.01]、[MD=-0.73,95%CI(-1.19,-0.28),P=0.002],且差异有统计学意义。结论盐酸米诺环素对减少种植体周围PD、SBI、PI及感染控制方面有明显的效果。Objective To evaluate the efficacy of minocycline hydrochloride in the treatment of peri-implantitis,and to provide evidence-based medicine for the treatment of peri-implantitis with minocycline hydrochloride.Methods The database we used concluded CNKI,VIP,Chinese Biomedical Literature,PubMed,Cochrane Library from inception to March 2019.The literatures were screened by two reviewers independently.Then,meta-analysis was performed using Rev Man 5.3 and Stata12.0.Results Seven randomized controlled trials were selected which involved 637 dental implants.Meta-analysis showed that the changes in Probing depth(PD)[MD=-0.64,95%CI(-1.14,-0.14),P=0.01],Sulcus bleeding index(SBI)[MD=-2.12,95%CI(-3.09,-1.15),P<0.01]and plaque index(PI)[MD=-0.73,95%CI(-1.19,-0.28),P=0.002]had significant statistical difference between minocycline hydrochloride group and control group.Conclusion In the short-term observation,the local application of minocycline hydrochloride plays an effective role in the therapy of peri-implantitis.

关 键 词：盐酸米诺环素 种植体周围炎 安慰剂 随机对照试验 META分析 

分 类 号：R783.3[医药卫生—口腔医学]