尼莫地平预防烟雾病血管重建术后脑梗死的效果分析  

Effect of nimodipine on preventing cerebral infarction in patients with moyamoya disease after revascularization

作　　者：观龙彬 黄书岚[1] 朱晓楠[1] 陶祥[1] 吴勇[1] 容嘉彬 徐海涛[1] GUAN Long-bin;HUANG Shu-lan;ZHU Xiao-nan;TAO Xiang;WU Yong;RONG Jia-bin;XU Hai-tao(Department of Neurosurgery,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院神经外科,武汉430060

出　　处：《中国临床神经外科杂志》2020年第4期206-208,共3页Chinese Journal of Clinical Neurosurgery

摘　　要：目的探讨尼莫地平预防烟雾病血管重建术后脑梗死的效果。方法回顾性分析2016年7月至2019年5月联合血管重建术治疗的73例烟雾病的临床资料。46例使用尼莫地平(观察组),27例未使用尼莫地平(对照组)。术后1周复查颅脑CT或DWI观察新发脑梗死。结果73例中,术后1周发生脑梗死19例,发生率为26.03%。观察组术后脑梗死发生率(17.39%,8/46)明显低于对照组(40.74%,11/27;P<0.05)。多因素logistic回归分析显示,未使用尼莫地平是烟雾病联合血管重建术后脑梗死独立危险因素(P<0.05)。结论烟雾病联合血管重建术后脑梗死发生率较高,使用尼莫地平可以有效预防预防脑梗死。Objective To explore the effect of nimodipine on preventing cerebral infarction in the patients with moyamoya disease after vascular reconstruction.Methods The clinical data of 73 patients with moyamoya disease treated by combined revascularization from July,2016 to May,2019 were retrospectively analyzed.Nimodipine was used in 46 patients(observation group),and was not in 27(control group).One week after the operation,the CT or DWI was used to observe the cerebral infarction.Results Of 73 patients,19 patients(26.03%)had cerebral infarction 1 week after operation.The incidence of postoperative cerebral infarction in the observation group(17.39%,8/46)was significantly lower than that(40.74%,11/27)in the control group(P<0.05).Multivariate logistic regression analysis showed that non-use of nimodipine was an independent risk factor for cerebral infarction after vascular reconstruction surgery(P<0.05).Conclusion The incidence of cerebral infarction is high in the patients with moyamoya disease after vascular reconstruction surgery,and the use of nimodipine can effectively prevent the cerebral infarction.

关 键 词：烟雾病 联合血管重睑术 尼莫地平 脑梗死 

分 类 号：R743[医药卫生—神经病学与精神病学] R651.12[医药卫生—临床医学]