丙种球蛋白、泼尼松治疗重症肌无力疗效分析  

Therapeutic Effect of Gamma Globulin and Prednisone on Myasthenia Gravis

作　　者：刘又玮 鞠波[1] LIU Youwei;JU Bo(Internal Medicine-Neurology,970 Hospital of The Joint Logistics Support Force,The Chinese People’s Liberation Army,Yantai Shandong 264000,China)

机构地区：[1]中国人民解放军联勤保障部队第970医院神经内科,山东烟台264000

出　　处：《中国继续医学教育》2020年第13期140-142,共3页China Continuing Medical Education

摘　　要：目的实施本次研究的目的在于探究临床重症肌无力患者采取丙种球蛋白联用泼尼松治疗的效果。方法调查本次研究的时间段为2018年5月-2019年5月,调查样本为医院接收治疗的重症肌无力患者118例,患者进行分组的主要依据为治疗方法的差异,采用丙种球蛋白联用泼尼松治疗的患者组成联合组,采用醋酸泼尼龙片治疗的患者组成对比组。观察分析两组患者的C3与IgG水平,并分析两组患者的TNF-α、IL-2、IL-6等炎性因子水平。结果联合组患者的C3与IgG水平低于G对比组,并且联合组患者的炎性因子水平都低于对比组,P<0.05。结论临床重症肌无力患者采取丙种球蛋白联合泼尼松治疗的疗效较佳,能够让患者的炎性因子发生明显减少。Objective The purpose of this study is to explore the effect of gamma globulin combined with prednisone in the treatment of myasthenia gravis. Methods 118 patients with myasthenia gravis who were treated in our hospital from May 2018 to May 2019 were investigated. The main basis for grouping patients was the difference of treatment methods. The patients treated with gamma globulin combined with prednisone were divided into combined group and the patients treated with prednisolone acetate tablets were divided into control group. The levels of C3 and IgG in the two groups were observed and analyzed. The levels of TNF-alpha, IL-2 and IL-6 in the two groups were also analyzed. Results The levels of C3 and IgG in the combined group were lower than those in the G control group, and the levels of inflammatory factors in the combined group were lower than those in the control group, P<0.05. Conclusion Gamma globulin combined with prednisone is effective in the treatment of myasthenia gravis, which can significantly reduce the incidence of inflammatory factors in patients with myasthenia gravis.

关 键 词：重症肌无力 丙种球蛋白 泼尼松 联合治疗 炎性因子 IGG 

分 类 号：R746[医药卫生—神经病学与精神病学]