血管平滑肌细胞自噬的激活与作用  

Activation of Autophagy in Vascular Smooth Muscle Cells and Its Roles

作　　者：王琛 赵振奥 赵自刚[2] WANG Chen;ZHAO Zhen-ao;ZHAO Zi-gang(Graduate School of Hebei North University,Zhangjiakou,Hebei 075000,China;Institute of Microcirculation,Hebei North University,Zhangjiakou,Hebei 075000,China)

机构地区：[1]河北北方学院研究生院,河北张家口075000 [2]河北北方学院微循环研究所,河北张家口075000

出　　处：《河北北方学院学报（自然科学版）》2020年第6期46-50,共5页Journal of Hebei North University:Natural Science Edition

基　　金：国家自然科学基金项目(No.81770492);河北省中医药管理局科研计划(No.2017213)。

摘　　要：血管平滑肌细胞(VSMCs)是血管壁的重要组成部分,是调节血压、向周围组织输送氧和营养物质的基础细胞之一。多种因素通过调节VSMCs自噬影响VSMCs的生存状态,引起VSMCs生物学行为的变化,从而参与血管相关疾病的发生与进展。以调节VSMCs自噬为靶向,可为寻找防治血管相关疾病策略提供新思路。Vascular smooth muscle cells(VSMCs)are the major cell type of vascular wall that regulates blood pressure,and delivers oxygen and nutrients to surrounding tissues.Multiple factors influence the survival of VSMCs through autophagy,resulting in the change of VSMC biological behavior.Furthermore,autophagy is involved in the occurrence and progress of blood vessel related-diseases.Therefore,balancing autophagy can provide new ideas for the prevention and treatment of vascular-related diseases.

关 键 词：血管平滑肌细胞 自噬 氧化应激 代谢 血管相关疾病 

分 类 号：R363[医药卫生—病理学]