Lifting the veil on the keratinocyte contribution to cutaneous nociception  

作　　者：Matthieu Talagas Nicolas Lebonvallet Francois Berthod Laurent Misery 

机构地区：[1]Univ Brest,LIEN,29200 Brest,France [2]Laboratoire d'Organogenese Experimentale(LOEX),University of Laval,Quebec,Canada [3]Department of Dermatology,Brest University Hospital,Brest,France [4]Univ Brest,BSAM(Institut Brestois de Sante Agro matiere),29200 Brest,France

出　　处：《Protein & Cell》2020年第4期239-250,共12页蛋白质与细胞（英文版）

摘　　要：Cutaneous nociception is essential to prevent individuals from sustaining injuries.According to the conventional point of view,the responses to noxious stimuli are thought to be exclusively initiated by sensory neurons,whose activity would be at most modulated by keratinocytes.However recent studies have demonstrated that epidermal keratinocytes can also act as primary nociceptive transducers as a supplement to sensory neurons.To enlighten our understanding of cutaneous nociception,this review highlights recent and relevant findings on the cellular and molecular elements that underlie the contribution of epidermal keratinocytes as nociceptive modulators and noxious sensors,both under healthy and pathological conditions.

关 键 词：KERATINOCYTE NOCICEPTION skin TRP PAIN inflammation 

分 类 号：Q2[生物学—细胞生物学]