LHX6 is essential for the migration of human pluripotent stem cell-derived GABAergic interneurons  

作　　者：Fang Yuan Kai-Heng Fang Yuan Hong Shi-Bo Xu Min Xu Yufeng Pan Yan Liu 

机构地区：[1]Institute for Stem Cell and Neural Regeneration,School of Pharmacy,Nanjing Medical University,Nanjing 211166,China [2]Key Laboratory of Developmental Genes and Human Disease,Institution of Life Sciences,Southeast University,Nanjing 2100096,China [3]State Key Laboratory of Reproductive Medicine,Nanjing Medical University,Nanjing 211166,China [4]Co-innovation Center of Neuroregeneration,Nantong University,Nantong 226019,China

出　　处：《Protein & Cell》2020年第4期286-291,共6页蛋白质与细胞（英文版）

基　　金：We thank Dr.Su-Chun Zhang(Waisman Center and WiCell Research Institute at the University of Wisconsin)for kindly providing the AAVS1-TALEN plasmids and crispr-cas9 plasmids.This study was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDA16010306);the National Natural Science Foundation of China Grants(Grant Nos.81922022,91849117,and 81471301);the National Key Research and Development Program of China(2019YFA0802703 and 2016YFC1306703);the Jiangsu Outstanding Young Investigator Program(BK20160044);the Jiangsu Province's Innovation Program,Postgraduate Research and Practice Innovation Program of Jiangsu Province.

摘　　要：Dear Editor,GABAergic interneurons(GIs)play an essential inhibitory role in regulating neural circuitry and neurological activities.Approximately 54%GABAergic interneuron population originated from medial ganglionic eminence(MGE)at E13.5 in rodents(Butt et al.,2005),and migrated from MGE to dorsal cortex tangentially starting at E13-14 after the GABAergic neurons become postmitotic.Dysfunction of GABAergic interneurons causes severe neurological diseases,such as autism,schizophrenia and depression.Recent years,many studies have shown transplantation of GIs improved the neuronal function of animal models such as epilepsy,neuropathic pain,and fear erasure(Braz et al.,2012;Cunningham et al.;Yang et al.,2016).Since migration is the intrinsic nature of GIs,regulation of GIs migration could be essential for cell therapy.However,the mechanism of human GIs migration remains unknown,which brings difficulties to control cell migration after transplantation.

关 键 词：originated MIGRATE MGE 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]