胆碱激酶α与原发性肝细胞癌预后的关系研究  

Effect of CHKαon the prognosis of patients with hepatocellular carcinoma

作　　者：封冰[1] 王伟[1] 翟景明[1] 姚国良[1] 范永刚[1] FENG Bing;WANG Wei;ZHAI Jingming;YAO Guoliang;FAN Yonggang(Department of Hepatobiliary and Pancreatic Surgery,the First Affiliated Hospital of Henan Science and Technology University,Luoyang 471000,China)

机构地区：[1]河南科技大学第一附属医院肝胆胰外科,河南洛阳471000

出　　处：《胃肠病学和肝病学杂志》2020年第4期446-449,共4页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的探讨胆碱激酶α(choline kinase alpha,CHKα)的表达对原发性肝细胞癌(hepatocellular carcinoma,HCC)患者预后的影响。方法选取2009年1月至2013年12月在河南科技大学第一附属医院接受根治性切除术治疗的HCC患者312例,应用实时荧光定量聚合酶链反应检测CHKα在HCC癌组织中的表达,并随访其生存状况。CHKα对HCC预后的预测价值采用受试者工作特征曲线(receiver operating characteristic,ROC)进行评估。单因素生存分析采用Kaplan-Meier并Log-rank检验,采用多因素分析Cox回归模型。结果截至2018年12月,312例HCC患者中,失访26例,随访率91.7%。在随访到的286例患者中,死亡177例。CHKα预测HCC死亡的最佳临界点为0.55,当CHKα为0.55时,CHKα预测HCC死亡的灵敏度为74.6%,特异度为83.5%;AUC曲线下面积为0.80。多因素Cox回归模型表明,较大肿瘤(HR=1.08,95%CI:1.03~1.14)、Child-Pugh B级(HR=1.14,95%CI:1.11~1.18)、CHKα低表达(HR=2.26,95%CI:1.92~2.39)是HCC患者死亡风险增加的独立危险因素。结论CHKα表达是HCC患者预后独立危险因素,CHKα表达下调者预后更差。Objective To investigate the effect of choline kinase alpha(CHKα)on the prognosis of patients with hepatocellular carcinoma(HCC).Methods A total of 312 patients with HCC who underwent surgical resection in our hospital from Jan.2009 to Dec.2013 were included.The expression of CHKαin HCC tumor tissues was detected by quantitative real-time polymerase chain reaction,and their survival status was followed-up.The receiver operating characteristic(ROC)curve was used to estimate the predictive value of CHKαfor the prognosis of HCC.Kaplan-Meier with Log-rank test were used for univariate analysis,and significant factors in univariate analysis were introduced into Cox regression model.Results At the end of Dec.2018,26 out of 312 HCC patients were lost to follow-up,with a follow-up rate of 91.7%.Among the 286 patients who had been followed-up,177 participants were died.The optimum cut-off value of CHKαfor predicting HCC death was 0.55.When CHKαwas 0.55,the sensitivity and specificity of CHKαfor predicting HCC death were 74.6%and 83.5%,respectively.And the area under AUC curve was 0.80.The results of multiple Cox regression model suggested that larger tumor(HR=1.08,95%CI:1.03-1.14),Child-Pugh B(HR=1.14,95%CI:1.11-1.18),and low expression of CHKα(HR=2.26,95%CI:1.92-2.39)were independent risk factors for increased mortality in HCC patients.Conclusion The expression of CHKαis an independent risk factor for prognosis of HCC patients,and the patients with CHKαdown-regulation have higher risk of death.

关 键 词：原发性肝细胞癌 胆碱激酶α 预后 

分 类 号：R735.7[医药卫生—肿瘤]