缺糖基转铁蛋白与线粒体同工酶在酒精性肝病中的临床应用  

Application of isoenzyme in alcoholic liver disease with carbohydrate deficient transferrin and aspartate aminotransferase mitochondrial isoenzyme

作　　者：王利茹 陶佳 杨萍 蔡永梅 WANG Liru;TAO Jia;YANG Ping;CAI Yongmei(Medical Experimental Center,General Hospital of Ningxia Medical University,Yinchuan 750004,China)

机构地区：[1]宁夏医科大学总医院医学实验中心,宁夏银川750004

出　　处：《宁夏医学杂志》2020年第3期254-256,共3页Ningxia Medical Journal

基　　金：宁夏自然科学基金项目(NZ15144)。

摘　　要：目的探讨缺糖基转铁蛋白(CDT)与天门冬氨酸氨基转移酶线粒体同工酶(m-AST)在酒精性肝病的诊断及监测中的应用价值。方法选取酒精性肝病患者60例(酒精组),非酒精性肝病患者60例(非酒精组),并选择同期在我院体检的健康者60例作为对照组,采集所有受检者治疗前或体检当天的血清样品,以及酒精组患者治疗4周后的血清样品,分别检测CDT、m-AST水平。结果酒精组患者的%CDT与m-AST水平均明显高于非酒精组及对照组(P<0.05);CDT检测的ROC曲线下面积为0.808,敏感性为81.67%,特异性为83.33%;m-AST检测的ROC曲线下面积为0.764,敏感性为91.67%,特异性为63.33%;2项指标联合检测的ROC曲线下面积为0.875,敏感性为93.33%,特异性为76.67%;治疗后,酒精性脂肪肝、酒精性肝炎、酒精性肝硬化患者的血清%CDT与m-AST水平均较治疗前明显降低(P<0.05)。结论 CDT及m-AST联合检测可提高诊断酒精性肝病的敏感性,且对疾病的治疗监测具有一定的临床价值。Objective To explore the value of CDT and m-AST in the diagnosis and monitor of alcoholic liver disease.Methods 60 patients with alcoholic liver disease(alcohol group),60 patients with nonalcoholic liver disease(non-alcohol group) were enrolled in the study,and 60 healthy cases were taken as control group. Serum samples were collected from all subjects before and after treatment,and serum samples were collected for 4 weeks after treatment. The levels of CDT and m-AST were detected respectively.Results The levels of CDT and m-AST in alcohol group were significantly higher than those in non-alcohol group and control group(P<0.05). The area under the ROC curve detected by CDT was 0.808,the sensitivity was 81.67%,and the specificity was 83.33%.The area under ROC curve detected by m-ast was 0.764,the sensitivity was 91.67%,and the specificity was 63.33%. The area under the ROC curve detected by the two indexes was 0.875,the sensitivity was 93.33%,and the specificity was 76.67%. After treatment,the levels of serum CDT and m-AST in patients with alcoholic fatty liver,alcoholic hepatitis and alcoholic cirrhosis were significantly lower than those before treatment(P<0.05).Conclusion Combined detection of CDT and m-AST can improve the sensitivity of alcoholic liver disease diagnosis,and the treatment of disease has a certain clinical value.

关 键 词：缺糖基转铁蛋白 天门冬氨酸氨基转移酶线粒体同工酶 酒精性肝病 

分 类 号：R575.1[医药卫生—消化系统]