多肽-N乙酰氨基半乳糖转移酶10在肺癌中的表达及意义  

Expression of polypeptide N-acetylgalactosaminyltransferase-10 in lung cancer

作　　者：蔡翠霞[1] 高媛[1] 刘玥 王涵多[1] CAI Cui-xia;GAO Yuan;LIU Yue;WANG Han-duo(School of Basic Medical Science,Guangdong Provincial Key Laboratory of Single Cell Technology and Application,Southern Medical University,Guangzhou 510515,China)

机构地区：[1]南方医科大学基础医学院,广东省生物芯片重点实验室,广州510515

出　　处：《解剖学报》2020年第2期206-210,共5页Acta Anatomica Sinica

基　　金：Natural Science Foundation of Guangdong Province(2015A030310468)。

摘　　要：目的探讨检测多肽-N乙酰氨基半乳糖转移酶10(ppGalNAc-T10)单细胞技术与应用蛋白在肺癌、乳腺癌和结肠癌中的表达。方法采用免疫组织化学检测ppGalNAc-T10在110例肺癌组织、100例乳腺癌组织和110例结肠癌组织中的表达;不同的肿瘤均有10例相对应的正常组织作为对照。结果同正常肺组织相比较,ppGalNAc-T10在肺癌组织中表达较低;且ppGalNAc-T10的表达与肿瘤侵袭深度相关(P<0.01)。PpGalNAc-T10蛋白在乳腺癌和结肠癌及其相对应的正常组织的表达差异无显著性。结论PpGalNAc-T10在肺癌中,有可能成为的1个有效标记蛋白。Objective The purpose of this study is to investigate the expression of the polypeptide Nacetylgalactosaminyltransferase-10(ppGalNAc-T10)protein in lung and breast and colon cancer.Methods Immunohistochemistry was used to analyse ppGalNAc-T10 expressions in 110 lung cancer tissues,100 breast cancer tissues and 110 colon cancer tissues.Meanwhile,different cancer has 10 cases of normal tissues as control.Results The expression of ppGalNAc-T10 in normal lung tissue was higher compared with that in lung cancer organizations,and ppGalNAc-T10 positive expression was found to be significantly associated with invasion depth of tumor(P<0.01).Pp Gal NAc-T10 protein expression in breast and colon cancer was no significantly difference than that in non-tumor breast and colon tissue.Conclusion Pp Gal NAc-T10 expression is a useful marker in lung cancer.

关 键 词：肺癌 乳腺癌 结肠癌 多肽-N乙酰氨基半乳糖转移酶10 人 

分 类 号：R735.1[医药卫生—肿瘤]