Clinical course of suspected small gastrointestinal stromal tumors in the stomach  

作　　者：Lian-Song Ye Yan Li Wei Liu Ming-Hong Yao Naveed Khan Bing Hu 

机构地区：[1]Department of Gastroenterology,West China Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China [2]Department of Epidemiology and Health Statistics,West China School of Public Health,Sichuan University,Chengdu 610041,Sichuan Province,China

出　　处：《World Journal of Gastrointestinal Surgery》2020年第4期171-177,共7页世界胃肠外科杂志（英文版）（电子版）

基　　金：Supported by National Key R&D Program of China,No.2017YFC0112300,No.2017YFC0112305.

摘　　要：BACKGROUND Gastric subepithelial lesions are frequently encountered during endoscopic examinations,and the majority of them are small and asymptomatic.Among these lesions,gastrointestinal stromal tumors(GISTs)are the major concern for patients and clinicians owing to their malignant potentials.Although previous guidelines suggested periodic surveillance for such small(≤20 mm)lesions,several patients and clinicians have still requested or prescribed repeated examinations or radical resection,posing extra medical burdens and risks.AIM To describe the clinical course of suspected small gastric GISTs and provide further evidence for surveillance strategy for tumor therapy.METHODS This single-center,retrospective study was conducted at West China Hospital,Sichuan University.Consecutive patients with suspected small gastric GISTs were reviewed from November 2004 to November 2018.GIST was suspected according to endoscopic ultrasonography features:hypoechoic lesions from muscularis propria or muscularis mucosa.Eligible patients with suspected small(≤20 mm)GISTs were included for analysis.Patients’demographic data,lesions’characteristics,and follow-up medical records were collected.RESULTS A total of 383 patients(male/female,121/262;mean age,54 years)with 410 suspected small gastric GISTs(1 lesion in 362 patients,2 lesions in 16,3 lesions in4,and 4 lesions in 1)were included for analysis.The most common location was gastric fundus(56.6%),followed by body(29.0%),cardia(12.2%),and antrum(2.2%).After a median follow-up of 28 mo(interquartile range,16-48;range,3-156),402 lesions(98.0%)showed no changes in size,and size of 8 lesions(2.0%)was increased(mean increment,10 mm).Of the 8 lesions with size increment,endoscopic or surgical resection was performed in 6 patients(5 GISTs and 1 leiomyoma).For other 2 remaining patients,unroofing biopsy or endoscopic ultrasound-guided fine-needle aspiration was carried out(2 GISTs),while no further change in size was noted over a period of 62-64 mo.CONCLUSION The majority of suspec

关 键 词：Endoscopic ultrasound-guided FINE-NEEDLE ASPIRATION Gastrointestinal STROMAL tumor Hypoechoic lesions STOMACH Surveillance strategy UNROOFING biopsy 

分 类 号：R735[医药卫生—肿瘤]