Multiple carcinosarcomas of the esophagus with adenocarcinomatous components: A case report  

作　　者：Hiroshi Okamoto Hiroshi Kikuchi Hiroshi Naganuma Takashi Kamei 

机构地区：[1]Department of Gastroenterological Surgery,Graduate School of Medicine,Tohoku University,Sendai 980-8574,Japan [2]Department of Surgery,South Miyagi Medical Center,Miyagi 989-1253,Japan [3]Department of Pathology,Sendai City Hospital,Sendai 982-8502,Japan

出　　处：《World Journal of Gastroenterology》2020年第17期2111-2118,共8页世界胃肠病学杂志（英文版）

摘　　要：BACKGROUND Carcinosarcoma(spindle cell carcinoma) of the esophagus is an extremely rare event;the etiology and origins of this neoplasm have not yet been determined.Epithelial-mesenchymal transition(EMT) has been associated with invasion and metastasis, and may be related to the generation of a stem cell population within this tumor.CASE SUMMARY We present the case of a 61-year-old male with nausea and fever. Upper gastrointestinal endoscopy revealed the presence of type 1 and 0-Ⅱc lesions located 35 cm from the incisors toward the esophago-gastric junction.Thoracoscopic esophagectomy was performed. Macroscopic analysis revealed three polypoid lesions in the abdominal esophagus that accompanied the main lesion in the lower thoracic esophagus and 0-Ⅱc lesions that spread continuously with them. Histologically, the lesions included proliferating spindle cells. Adenocarcinomatous components were detected in a section near the foot, and squamous cell carcinoma was identified in the mucosa at the base of the tumor.The patient was diagnosed with multiple carcinosarcomas, staged at pT1b(SM3),pN1(#110, #7), cM0, Stage Ⅱ(sarcomatous metastasis to the lymph nodes).Spindle cells did not express E-cadherin but were positive for EMT markers,including zinc finger E-box-binding homeobox 1, TWIST, and snail family transcriptional repressor 2. The patient has experienced no recurrence at 5 years and 2 mo after surgery.CONCLUSION This report suggests that multiple sarcomatous tumors may be generated from primary squamous cell carcinoma via mechanisms related to EMT.

关 键 词：ESOPHAGUS MULTIPLE carcinosarcomas MULTIPLE spindle cell CARCINOMAS Epithelial-mesenchymal TRANSITION Epithelial-mesenchymal TRANSITION markers Case report 

分 类 号：R735.1[医药卫生—肿瘤]