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作 者:Atif Sher Muhammad Tariq Ashraf Ayaz Mir Syed Alishan Faiza Farooq Ali Ammar Musa Karim Syed Nadeem Hassan Rizvi Tahir Saghir Jawaid Akbar Sial Naveed Ullah Khan
机构地区:[1]Department of Adult Cardiology,National Institute of Cardiovascular Diseases,Karachi 75510,Pakistan [2]Department of Clinical Research,National Institute of Cardiovascular Diseases,Karachi 75510,Pakistan
出 处:《World Journal of Cardiology》2020年第4期136-143,共8页世界心脏病学杂志(英文版)(电子版)
基 金:support of the staff members of the Clinical Research Department of the National Institute of Cardiovascular Diseases(NICVD)Karachi,Pakistan.
摘 要:BACKGROUND Even though percutaneous coronary intervention(PCI)improved the survival of patients with acute myocardial infarction,still multivessel coronary artery disease remains an important factor burdening prognosis and it is being associated with a worse prognosis compared to single-vessel disease(SVD).AIM To compare the clinical profile and outcomes after the primary PCI in young patients with SVD vs multivessel disease(MVD).METHODS The retrospective cohort of patients were divided into two groups:SVD and MVD group.The study population consisted of both male and female young(≤45 years)patients presented with ST-elevation myocardial infarction(STEMI)at the National Institute of Cardiovascular Disease,Karachi,Pakistan and undergone primary PCI from 1 st July 2017 to 31 st March 2018.Pre and postprocedure management of the patients was as per the guidelines and institutional protocols.RESULTS A total of 571 patients with STEMI,≤45 years were stratified into two groups by the number of vessels involved,342(59.9%)with SVD and 229(40.1%)with MVD.The average age of these patients was 39.04±4.86 years.A lower prevalence of hypertension and diabetes was observed in SVD as compare to MVD group(25.1%vs 38%,P<0.01;11.7%vs 27.5%,P<0.001)respectively.While,smoking was more prevalent among the SVD group as compare to MVD group(36.3%vs 28.4%,P=0.05).The high-C Lesion was observed in a significantly higher number of younger patients with MVD as compared to SVD group(48.8%vs 39.2%,P=0.021).Post-procedure thrombolysis in myocardial infarction flow grade was found to be not associated with the number of diseased vessels with a P value of 0.426 and thrombolysis in myocardial infarction flow grade III was observed in 98%vs 96.5%of the patients is SVD vs MVD group.CONCLUSION The MVD comprised of around 40%of the young patients presented with STEMI.Also,this study shows that diabetes and hypertension have a certain role in the pathogenesis of multivessel diseases,therefore,preventive measures for diabetes and hypertension can
关 键 词:Young MULTIVESSEL DISEASE Primary percutaneous CORONARY intervention STelevation myocardial INFARCTION PREMATURE CORONARY artery diseases Single-vessel DISEASE
分 类 号:R542.22[医药卫生—心血管疾病]
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