COVID-19 compared to other epidemic coronavirus diseases and theflu  

作　　者：James A Ayukekbong Michel L Ntemgwa Solange A Ayukekbong Eta E Ashu Terence A Agbor 

机构地区：[1]Infection Prevention and Control Unit,St Joseph’s Hospital,Elliot Lake,ON P5A 2R3,Canada [2]EpiTech Public Health,Nanaimo,BC V9R 0H7,Canada [3]Natural and Non-prescription Health Products Directorate,Health Products and Food Branch,Health Canada,Ottawa,ON K1A 0K9,Canada [4]Cancer Care Ontario,Toronto,ON M5P 3L6,Canada [5]DynaLIFE Medical Labs,Edmonton,AB T5J 5E2,Canada [6]Laboratory Medicine and Pathology,University of Alberta,Edmonton,Alberta,AB T6G 2R3,Canada

出　　处：《World Journal of Clinical Infectious Diseases》2020年第1期1-13,共13页世界临床传染病学杂志

摘　　要：Coronaviruses are among the largest group of known positive-sense RNA viruses with a wide range of animal hosts as reservoir. In the last two decades,newly evolved coronaviruses such as the severe acute respiratory syndrome coronavirus(SARS-CoV) which caused the infamous 2002 outbreak, the Middle East respiratory syndrome coronavirus(MERS-CoV) which caused an outbreak in 2012, and now the SARS-CoV-2 [responsible for the current coronavirus disease 2019(COVID-19)] have all posed notable threats to global public health.But, how does the current COVID-19 outbreak compare with previous coronaviruses diseases? In this review, we look at the key differences between SARS-CoV, MERS-CoV, and SARS-CoV-2, and examine challenges in determining accurate estimates of the severity of COVID-19. We discuss coronavirus outbreaks in light of key outbreak severity indicators including,disease fatality, pathogen novelty, ease of transmission, geographical range, and outbreak preparedness. Finally, we review clinical trials of emerging treatment modalities and provide recommendations on the control of COVID-19 based on the mode of transmission of the coronaviruses. We also recommend the development and use of a standardized predictive epidemic severity models to inform future epidemic response.

关 键 词：Severe acute RESPIRATORY syndrome SARS Middle East RESPIRATORY syndrome MERS COVID-19 SARS-CoV2 CORONAVIRUSES Influenza Flu RESPIRATORY viruses 

分 类 号：R37[医药卫生—病原生物学]