CORONAVIRUSES

作品数：54被引量：113H指数：6
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The potential mechanisms and material basis of Fuzheng Jiedu decoction broad-spectrum inhibiting coronaviruses
《Virologica Sinica》2025年第1期125-136,共12页Ke Liu Bixia Hong Shi-Ting He Siying Du Jiayi Ke Lili Tian Tao Tao Yihan Zhang Kelin Li Han Chang Mengzhe Li Xiaoping An Lihua Song Zhongde Zhang Liang Liu Hudan Pan Huahao Fan Yigang Tong 
supported by National Key Research and Development Program of China(grant No.2022YFC0867500,2020YFA0712102);National Natural Science Foundation of China(grant No.82151224,82202492);Fundamental Research Funds for Central Universities(grant No.QNTD 2023-01);Nutrition and Care of Maternal&Child Research Project of Biostime Institute of Nutrition&Care(grant No.2023BINCMCF28);State Key Laboratory of Pathogen and Biosecurity of China(grant No.SKLPBS2438);State Key Laboratory of Component-based Chinese Medicine(grant No.CBCM2024204).
Traditional Chinese medicine has unique advantages in preventing and treating COVID-19,and Fuzheng Jiedu decoction(FZJDD)was reported to be effective against COVID-19 in clinical trials.To investigate the potential me...
关键词：Fuzheng jiedu decoction SARS-CoV-2 Broad-spectrum anti-coronavirus Traditional Chinese medicine Caffeic acid Octyl gallate 
Computational optimization of a pan-coronavirus fusion inhibitory peptide targeting spike's heptapeptide repeat region
《Biosafety and Health》2025年第1期44-58,共15页Peixiang Gao Shuo Liu Xiaojing Chi Xinhui Zhang Xiuying Liu Xuehua Yang Huarui Duan Jingya Zhou Weijin Huang Wei Yanag 
supported by the National Natural Science Foundation of China(U22A20553 and 82241064);the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2021-I2M-1-038, 2022-I2M-1-021).
In the past two decades,highly pathogenic coronaviruses(CoVs),such as severe acute respiratory syndrome coronavirus(SARS-CoV),Middle East respiratory syndrome coronavirus(MERS-CoV),and severe acute respiratory syndrom...
关键词：Coronaviruses(CoVs) Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) Fusion inhibitors Computational design 
Assessing the inhibition efficacy of clinical drugs against the main proteases of SARS-CoV-2 variants and other coronaviruses
《Quantitative Biology》2024年第3期324-328,共5页Wenlong Zhao Cecylia SLupala Shifeng Hou Shuxin Yang Ziqi Yan Shujie Liao Xuefei Li Nan Li 
National Key Research and Development Program of China,Grant/Award Number:2023YFA0913900;National Natural Science Foundation of China,Grant/Award Numbers:31971354,32100146,32170672,32271501。
The rapid evolution of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)mainly due to its high mutation rate and rapid viral replication,has led to new variants resistant to the available vaccines and monocl...
关键词：drug resistance enzymatic activity main protease SARS-CoV-2 
Individual virome analysis reveals the general co-infection of mammal-associated viruses with SARS-related coronaviruses in bats
《Virologica Sinica》2024年第4期565-573,共9页Hao-Rui Si Ke Wu Jia Su Tian-Yi Dong Yan Zhu Bei Li Ying Chen Yang Li Zheng-Li Shi Peng Zhou 
supported by the National Key R&D Program of China(2021YFC2300901 to P.Z.);China Natural Science Foundation for outstanding scholars(82325032 to P.Z.);the Self-Supporting Program of Guangzhou Laboratory(SRPG22-001 to P.Z.;GZNL2023A01001 to ZLS).
Bats are the natural reservoir hosts for SARS-related coronavirus(SARSr-CoV)and other highly pathogenic microorganisms.Therefore,it is conceivable that an individual bat may harbor multiple microbes.However,there is l...
关键词：Bat Microbiome SARS-related coronavirus CO-INFECTION Alphacoronavirus 
Antigen epitopes of animal coronaviruses:a mini-review
《Animal Diseases》2024年第1期19-26,共8页Mingjun Su Guanghui Zheng Xiangwen Xu Houhui Song 
supported by the Natural Science Foundation of Zhejiang Province(Q23C180006);the Zhejiang A&F University Talent Initiative Project(118-203402005901).
Coronaviruses are widespread in nature and can infect mammals and poultry,making them a public health concern.Globally,prevention and control of emerging and re-emerging animal coronaviruses is a great challenge.The m...
关键词：Animal coronavirus Antigen epitope B-cell epitope T-cell epitope Immune responses Vaccines 
Lycorine derivative effectively inhibits the replication of coronaviruses both in vitro and in vivo被引量：1
《hLife》2024年第2期75-87,共13页Liang Shen Jianzhong Zhao Ying Xia Junjie Lu Jiali Sun Jian Tang Hui Xing Lijuan Yin Yang Yang Chunhua Wang 
supported by National Natural Science Foundation of China (82002192,32302218);General project of Natural Science Foundation of Hubei Province (2019CFA016,2022CFB539,2022CFD107);Young and Middle-aged Talents Project of Hubei Provincial Education Department (Q20222605);Tianjin Municipal Science and Technology Committee (21JCQNJC01410);China Postdoctoral Science Foundation (2021M702460);Science and Technology Plan (in the field of medical and health care)of Xiangyang (2022YL05B,2022YL12A).
The established and ongoing prevalence of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and seasonal human coronaviruses(HCoV)like HCoV-OC43,HCoV-NL63,and HCoV-229E,pose a continuous threat to public heal...
关键词：BROAD-SPECTRUM antiviral drug lycorine derivative Ly-8 
Is the time right for systematically serotyping SARS-related coronaviruses?被引量：2
《hLife》2024年第1期4-5,共2页Chee Wah Tan Lin-Fa Wang 
IS THERE A NEED FOR SEROTYPING?The emergence and rapid selection of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)immune escape variants have exerted significant challenges in many different ways,from pub...
关键词：IMMUNITY SARS establishing 
Pangolin HKU4-related coronaviruses found in greater bamboo bats from southern China
《Virologica Sinica》2023年第6期868-876,共9页Min Guo Kai Zhao Xingwen Peng Xiangyang He Jin Deng Bo Wang Xinglou Yang Libiao Zhang 
the Special Foundation for the National Science and Technology Basic Research Program of China(2021FY100303);the Guangdong Provincial Science and Technology Program(2021B1212050021,2021B1212110003);the GDAS Special Project of Science and Technology Development(2021GDASYL-20210103052);the Young Top-notch Talent Cultivation Program of Hubei Province and the Youth Innovation Promotion Association of the Chinese Academy of Sciences(CAS)(2019328).
Coronavirus(CoV)spillover originating from game animals,particularly pangolins,is currently a significant concern.Meanwhile,vigilance is urgently needed for coronaviruses carried by bats,which are known as natural res...
关键词：CORONAVIRUS Pangolin HKU4r-CoV Bat HKU4r-CoV Tylonycteris robustula Spillover risk 
Identification of a receptor tyrosine kinase inhibitor CP-724714 inhibits SADS-CoV related swine diarrhea coronaviruses infection in vitro
《Virologica Sinica》2023年第5期778-786,共9页Ling Zhou Cheng Li Ruiyu Zhang Qianniu Li Yuan Sun Yaoyu Feng Tian Lan Jingyun Ma 
This work was funded by the Guangdong Major Project of Basic and Applied Basic Research(No.2020B0301030007);the Natural Science Foundation of Guangdong Province(2022A1515012473,2020A1515010220);the Science and Technology Program of Guangzhou City of China(2023B03J1310.)。
The outbreak of the COVID-19 epidemic in 2020 has caused unprecedented panic among all mankind,pointing the major importance of effective treatment.Since the emergence of the swine acute diarrhea syndrome coronavirus(...
关键词：SADS-CoV CORONAVIRUS Antiviral agents HER2 CP-724714 
Nanostructured biohybrid material with wide-ranging antiviral action
《Nano Research》2023年第8期11455-11463,共9页Noelia Losada-Garcia Angela Vazquez-Calvo David Ortega-Alarcon Olga Abian Adrian Velazquez-Campoy Pilar Domingo-Calap Antonio Alcami Jose M.Palomo 
supported by the Spanish National Research Council(CSIC)(projects Intramural Grant 202020E254);CSIC PTI-Global Health SGL2103036(J.M.P);European Union(Nextgeneration EU).Authors thank Dr.Martinez from Novozymes;was supported by Fundación hna(A.V-C.and O.A.).P.D-C.was financially supported by a Ramón y Cajal contract RYC2019-028015-I funded by MCIN/AEI.
Respiratory pathogens kill more people than any other infectious agent each year worldwide.Development of novel,economically friendly,sustainable,and highly efficient materials against viruses is a major challenge.Her...
关键词：antiviral compound CORONAVIRUSES copper nanoparticles NANOBIOTECHNOLOGY viruses 
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