Is the time right for systematically serotyping SARS-related coronaviruses?  

作　　者：Chee Wah Tan Lin-Fa Wang 

机构地区：[1]Department of Microbiology and Immunology,Yong Loo Lin School of Medicine,National University of Singapore,Singapore City,Singapore [2]Duke-NUS Medical School,Singapore City,Singapore

出　　处：《hLife》2024年第1期4-5,共2页健康科学（英文）

摘　　要：IS THERE A NEED FOR SEROTYPING?The emergence and rapid selection of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)immune escape variants have exerted significant challenges in many different ways,from public health response to vaccine boosting strategy and monitoring of herd immunity against future variants or related severe acute respiratory syndrome(SARS)related coronaviruses(SARSr-CoVs).The Omicron sub-variants,which differ substantially from the pre-Omicron variants,are circulating worldwide and continuing to evolve extensively through mutations and/or recombination predominantly in the spike protein,mainly due to immune-selective pressure.Despite their phylogenetically close relationship to ancestral SARS-CoV-2,antigenically,Omicron variants are very different from the original strain.It is therefore very natural to raise the question whether we need a better way to classify and differentiate those CoVs which are genetically very similar,but antigenically quite distinct.Serotyping of viruses is a common practice for many known virus groups,most notably for human papillomavirus(HPV)and dengue virus(DENV)[1,2].The concept of CoV serotypes was not new and has been applied to study the antigenicity of feline CoVs[3].The possibility of establishing distinctive serotypes for the SARS-CoV-2 virus was first raised by Simon-Loriere and Schwartz in 2022[4].Serotyping SARS-CoV-2 is expected to help more scientifically define the differences between variants and facilitate more targeted diagnostics,therapeutics,and vaccine development.

关 键 词：IMMUNITY SARS establishing 

分 类 号：R373[医药卫生—病原生物学]