BROAD-SPECTRUM

作品数：131被引量：387H指数：10
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相关领域：农业科学更多>>
相关作者：金雁薛小燕刘慰华刘克锋刘永光更多>>
相关机构：哈尔滨商业大学第四军医大学北京林业大学北京农学院更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金广东省自然科学基金更多>>
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Enabling the immune escaped etesevimab fully-armed against SARS-CoV-2 Omicron subvariants including KP.2
《hLife》2025年第3期132-145,共14页Chao Su Juanhua He Yufeng Xie Yu Hu Xin Li Shitong Qiao Peipei Liu Min Huang Rong Zhang Liang Wang Zhen Chang Wenqiao Sun Ke Xu Jing Zhang Longxing Cao Pengcheng Han Xin Zhao Jianxun Qi Qihui Wang Mengsu Yang George Fu Gao 
supported by the National Natural Science Foundation of China(82225021);the National Key R&D Program of China(2022YFC2303403,2021YFA1300803,2021YFA1301404).
Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is continuously evolving since 2019.Some monoclonal antibodies(mAbs)have been developed and widely used,such as etesevimab(CB6)developed by Eli-Lilly/Junshi.H...
关键词：etesevimab(CB6) severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) receptor-binding domain(RBD) broad-spectrum and affinity-mature antibody design(BAADesign) antibody 
Advancing RAS inhibition:broad-spectrum targeting and tumor-selective activity of RMC-7977 in cancer therapy
《Science China(Life Sciences)》2025年第2期586-587,共2页Qunli Xiong Yaguang Zhang 
supported by the National Natural Science Foundation of China(82203447);the Natural Science Foundation of Sichuan,China(2022NSFSC1424);the Postdoctoral Research Project,West China Hospital,Sichuan University(18HXBH068)。
In cancer,the proto-oncogene RAS frequently mutates at codons 12,13,and 61,with these mutations propelling tumor progression by locking RAS proteins in their active,GTP-bound state(Pylayeva-Gupta et al.,2011;Yang et a...
关键词：cancer LUNG 
The potential mechanisms and material basis of Fuzheng Jiedu decoction broad-spectrum inhibiting coronaviruses
《Virologica Sinica》2025年第1期125-136,共12页Ke Liu Bixia Hong Shi-Ting He Siying Du Jiayi Ke Lili Tian Tao Tao Yihan Zhang Kelin Li Han Chang Mengzhe Li Xiaoping An Lihua Song Zhongde Zhang Liang Liu Hudan Pan Huahao Fan Yigang Tong 
supported by National Key Research and Development Program of China(grant No.2022YFC0867500,2020YFA0712102);National Natural Science Foundation of China(grant No.82151224,82202492);Fundamental Research Funds for Central Universities(grant No.QNTD 2023-01);Nutrition and Care of Maternal&Child Research Project of Biostime Institute of Nutrition&Care(grant No.2023BINCMCF28);State Key Laboratory of Pathogen and Biosecurity of China(grant No.SKLPBS2438);State Key Laboratory of Component-based Chinese Medicine(grant No.CBCM2024204).
Traditional Chinese medicine has unique advantages in preventing and treating COVID-19,and Fuzheng Jiedu decoction(FZJDD)was reported to be effective against COVID-19 in clinical trials.To investigate the potential me...
关键词：Fuzheng jiedu decoction SARS-CoV-2 Broad-spectrum anti-coronavirus Traditional Chinese medicine Caffeic acid Octyl gallate 
Molecular Evolution of Rice Blast Resistance Gene bsr-d1
《Rice science》2024年第6期700-711,共12页LI Wei ZHANG Mengchen YANG Yaolong WENG Lin HU Peisong WEI Xinghua 
supported by the National Key Research and Development Program of China (Grant No.2023YFD1202600);the Zhejiang Lab independently establishes research projects (Research and Development of Intelligent Technologies and Platforms for Rice Breeding,Grant No.2021PE0AC05);the Natural Science Foundation of Zhejiang Province,China (Grant No.LQ22C130006)。
Rice blast,caused by the fungus Magnaporthe oryzae,reduces rice yields by 10%to 35%.Incorporating blast resistance genes into breeding programs is an effective strategy to combat this disease.Understanding the genetic...
关键词：broad-spectrum resistance bsr-d1 gene evolution Magnaporthe oryzae resistance breeding 
Fine-tuning of the dual-role transcription factor WRKY8 via differential phosphorylation for robust broad-spectrum plant immunity
《Plant Communications》2024年第12期91-109,共19页Chun-Xiu Ren Song-Yu Chen Yu-Han He You-Ping Xu Juan Yang Xin-Zhong Cai 
National Natural Science Foundation of China(no.31871947);Zhejiang Science and Technology Major Program on Agricultural New Variety Breeding(no.2021C02064);Hainan Provincial Natural Science Foundation of China(no.324CXTD430);Zhejiang Provincial Natural Science Foundation of China(no.LZ18C140002).
Plants perceive pathogen-associated molecular patterns(PAMPs)using plasma-membrane-localized pattern recognition receptors(PRRs)to activate broad-spectrum pattern-triggered immunity.However,the regulatory mechanisms t...
关键词：WRKY8 RLP23 CERK1 calcium-dependent protein kinases PBL19 plant immunity Sclerotinia sclerotiorum 
Lr34/Yr18/Sr57/Pm38 confers broad-spectrum resistance to fungal diseases via sinapyl alcohol transport for cell wall lignification in wheat被引量：1
《Plant Communications》2024年第12期161-177,共17页Yichen Zhang Guang Chen Yiming Zang Sridhar Bhavani Bin Bai Wei Liu Miaomiao Zhao Yikeng Cheng Shunda Li Wei Chen Wenhao Yan Hailiang Mao Handong Su Ravi PSingh Evans Lagudah Qiang Li Caixia Lan 
National Natural Science Foundation of China(grant nos.31861143010 and 32372173);National Key Research and Development Program of China(grants 2022YFD1201300 and 2022YFD1201500);Fundamental Research Funds for the Central Universities(2662020ZKPY005);Hubei Hongshan Laboratory(2022hspy001,2021hskf008,and 2022hspy010).
The widely recognized pleiotropic adult plant resistance gene Lr34 encodes an ATP-binding cassette transporter and plays an important role in breeding wheat for enhanced resistance to multiple fungal diseases. Despite...
关键词：Lr34 adult plant resistance disease resistance LIGNIN TaCOMT-3B 
Structural engineering of antimicrobials for optimal broad-spectrum activity
《Green Chemical Engineering》2024年第4期473-482,共10页Arunmozhiarasi Armugam Diane S.W.Lim Siti Nurhanna Riduan Shook Pui Chan Jerome Asugan Yugen Zhang 
supported by the Institute of Bioengineering and Bioimaging(IBB),Institute of Sustainability for Chemicals,Energy and Environment(ISCE2),Agency for Science,Technology and Research(A*Star),and BMRC Central Research Fund(CRF,ATR)
Antimicrobial materials are a crucial component in eradicating and managing the spread of infectious diseases.They are expected to act on a broad-spectrum of microbes,including emerging pathogens which could cause the...
关键词：BROAD-SPECTRUM ANTIMICROBIAL Polyimidazolium STRUCTURE-FUNCTION Membrane active 
Giant infrared bulk photovoltaic effect in tellurene for broad-spectrum neuromodulation
《Light(Science & Applications)》2024年第11期2812-2823,共12页Zhen Wang Chunhua Tan Meng Peng Yiye Yu Fang Zhong Peng Wang Ting He Yang Wang Zhenhan Zhang Runzhang Xie Fang Wang Shuijin He Peng Zhou Weida Hu 
supported by the National Key Research and Development Program of China(Grant No.2023YFB3611400);National Natural Science Foundation of China(Grant Nos.62327812,62361136587,62475275 and 62105349);Shanghai Natural Science Foundation(Grant Nos.21ZR1473900 and 22ZR1441500);Shanghai Sailing Program(Grant No.21YF1454900);National Science Centre,Poland(Grant No.SHENG3-UMO-2023/48/Q/ST7/00144).
Given the surpassing of the Shockley-Quiesser efficiency limit in conventional p-n junction photovoltaic effect,bulk photovoltaic effect(BPVE)has garnered significant research interest.However,the BPVE primarily focus...
关键词：effect SPECTRUM ULTRAVIOLET 
A small molecule compound targeting hemagglutinin inhibits influenza A virus and exhibits broad-spectrum antiviral activity
《Acta Pharmacologica Sinica》2024年第11期2380-2393,共14页Yin-yan Li Guo-dong Liang Zhi-xuan Chen Ke Zhang Jin-long Liang Lin-rui Jiang Si-zu Yang Feng Jiang Shu-wen Liu Jie Yang 
the National Natural Science Foundation of China(Grant numbers 82073897,82373915);the Science and Technology Innovation Project of Guangdong Medical Products Administration(Grant numbers S2021ZDZ042).
Influenza A virus(IAV)is a widespread pathogen that poses a significant threat to human health,causing pandemics with high mortality and pathogenicity.Given the emergence of increasingly drug-resistant strains of IAV,...
关键词：small molecule compound antiviral activity influenza A virus HEMAGGLUTININ entry inhibitor 
Rifaximin discontinuation during broad-spectrum antibiotic treatment in critically ill patients with hepatic encephalopathy
《World Journal of Hepatology》2024年第11期1356-1360,共5页Lorenzo Ridola Alessandro Mari 
Hepatic encephalopathy(HE)is one of the main complications of cirrhosis,characterized by a wide spectrum of neuropsychiatric alterations that lead to an increase in mortality,morbidity and recurrent hospitalizations.D...
关键词：Hepatic encephalopathy Rifaximin discontinuation Broad-spectrum antibiotics Critically ill patients Intensive care unit 
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