HEMAGGLUTININ

作品数：86被引量：159H指数：8
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相关领域：医药卫生农业科学更多>>
相关作者：高福马中良王波刘连芬刘超更多>>
相关机构：中国科学院北京大学上海大学聊城大学更多>>
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Random forest algorithm reveals novel sites in HA protein that shift receptor binding preference of the H9N2 avian influenza virus
《Virologica Sinica》2025年第1期109-117,共9页Yuncong Yin Wen Li Rujian Chen Xiao Wang Yiting Chen Xinyuan Cui Xingbang Lu David M.Irwin Xuejuan Shen Yongyi Shen 
supported by the National Natural Science Foundation of China(32273037 and 32102636);the Guangdong Major Project of Basic and Applied Basic Research(2020B0301030007);Laboratory of Lingnan Modern Agriculture Project(NT2021007);the Guangdong Science and Technology Innovation Leading Talent Program(2019TX05N098);the 111 Center(D20008);the double first-class discipline promotion project(2023B10564003);the Department of Education of Guangdong Province(2019KZDXM004 and 2019KCXTD001).
A switch from avian-typeα-2,3 to human-typeα-2,6 receptors is an essential element for the initiation of a pandemic from an avian influenza virus.Some H9N2 viruses exhibit a preference for binding to human-typeα-2,...
关键词：H9N2 Hemagglutinin(HA) Receptor binding preference Random forest algorithm Host shift Interspecies transmission 
A small molecule compound targeting hemagglutinin inhibits influenza A virus and exhibits broad-spectrum antiviral activity
《Acta Pharmacologica Sinica》2024年第11期2380-2393,共14页Yin-yan Li Guo-dong Liang Zhi-xuan Chen Ke Zhang Jin-long Liang Lin-rui Jiang Si-zu Yang Feng Jiang Shu-wen Liu Jie Yang 
the National Natural Science Foundation of China(Grant numbers 82073897,82373915);the Science and Technology Innovation Project of Guangdong Medical Products Administration(Grant numbers S2021ZDZ042).
Influenza A virus(IAV)is a widespread pathogen that poses a significant threat to human health,causing pandemics with high mortality and pathogenicity.Given the emergence of increasingly drug-resistant strains of IAV,...
关键词：small molecule compound antiviral activity influenza A virus HEMAGGLUTININ entry inhibitor 
C1QTNF5 is a novel attachment factor that facilitates the entry of influenza A virus
《Virologica Sinica》2024年第2期277-289,共13页Lei Yu Xinjin Liu Xiaoqin Wei Junrui Ren Xueyun Wang Shuwen Wu Ke Lan 
supported by National Natural Science Foundation of China(32188101 and 81930060).
Influenza A virus(IAV)binds sialic acid receptors on the cell surface to enter the host cells,which is the key step in initiating infection,transmission and pathogenesis.Understanding the factors that contribute to th...
关键词：C1QTNF5 Influenza A virus Viral entry HEMAGGLUTININ Attachment factor 
Involvement of Dectin-2 in the Innate Inflammatory Response Triggered by Influenza Virus Hemagglutinin
《Advances in Infectious Diseases》2023年第3期478-497,共20页Hideki Yamamoto Chikako Tomiyama Sho Yamasaki Shinobu Saijo Yoichiro Iwakura Kazuyoshi Kawakami 
C-type lectin receptors (CLRs) are representative pattern recognition receptors that recognize microbial polysaccharides expressed on antigen-presenting cells. In the present study, we carried out further detailed ana...
关键词：C-Type Lectin Receptors Influenza Virus Innate Immunity Type I Interferon 
Enhanced pathogenicity and transmissibility of H9N2 avian influenza virus in mammals by hemagglutinin mutations combined with PB2-627K被引量：5
《Virologica Sinica》2023年第1期47-55,共9页Kaituo Liu Yaqian Guo Huafen Zheng Zhuxing Ji Miao Cai Ruyi Gao Pinghu Zhang Xiaowen Liu Xiulong Xu Xiaoquan Wang Xiufan Liu 
supported by the National Key Research and Development Project of China:2021YFD1800202;by the National Natural Science Foundation of China:31772755,32072892,32072832;by the Earmarked Fund for China Agriculture Reasearch System:CARS-40;by the Priorty Academic Program Development of Jiangsu Higher Education Institutions(PAPD).
H9N2 avian influenza viruses(AIVs)circulate globally in poultry and have become the dominant AIV subtype in China in recent years.Previously,we demonstrated that the H9N2 virus(A/chicken/Eastern China/SDKD1/2015)natur...
关键词：H9N2 Hemagglutinin(HA) PB2-627K Mammalian adaptation PATHOGENICITY TRANSMISSIBILITY 
Transmembrane domain of IFITM3 is responsible for its interaction with influenza virus HA_(2) subunit
《Virologica Sinica》2022年第5期664-675,共12页Wang Xu Yuhang Wang Letian Li Xiaoyun Qu Quan Liu Tiyuan Li Shipin Wu Ming Liao Ningyi Jin Shouwen Du Chang Li 
supported by the National Natural Science Foundation of China (31702210, 31972719);the CAMS Innovation Fund for Medical Sciences (2020–12M-5-001)
Interferon-inducible transmembrane protein 3(IFITM3)inhibits influenza virus infection by blocking viral membrane fusion,but the exact mechanism remains elusive.Here,we investigated the function and key region of IFIT...
关键词：Interferon-inducible transmembrane protein 3 (IFITM3) Influenza virus Hemagglutinin(HA) INTERACTION Transmembrane domain 
Apoferritin nanoparticle based dual-antigen influenza conjugate vaccine with potential cross-protective efficacy against heterosubtypic influenza virus
《Particuology》2022年第5期56-64,共9页Yanan Sheng Jiangxue Wei Zhengjun Li Zhiguo Su Guanghui Ma Songping Zhang 
supported by the National Natural Science Foundation of China(Nos.21821005,31970872).
Ferritin nanoparticles with self-assembling properties have been widely explored as vaccine carrier by displaying foreign antigens through genetic fusion strategy.In the present work,an apoferritin(AFt)nanoparticle wa...
关键词：Influenza vaccine Apoferritin nanoparticle HEMAGGLUTININ M2e Conjugate vaccine 
Bioengineered pseudovirus nanoparticles displaying the HA1 antigens of influenza viruses for enhanced immunogenicity被引量：2
《Nano Research》2022年第5期4181-4190,共10页Ming Xia Md Rejaul Hoq Pengwei Huang Wen Jiang Xi Jiang Ming Tan 
The research described in this study was supported by the National Institute of Allergy and Infectious Diseases(NIAID,No.R56 AI148426-01A1 to M.T.);Cincinnati Children Hospital Medical Center(CCHMC,Innovation Funds 2018-2020,GAP Fund 2020-2021,and Research Innovation and Pilot Grant 2020-2021 to M.T.);the Center for Clinical and Translational Science and Training(CCTST)of the University of Cincinnati College of Medicine(Pilot Collaborative Studies Grant 2018-2019 to M.T.);that was supported by the National Center for Advancing Translational Sciences of the National Institutes of Health(No.UL1TR001425).
Even with implementation of current influenza vaccines,influenza still claims up to 500,000 lives worldwide annually,indicating a need for a better vaccine strategy.We have developed a technology to generate unique S_...
关键词：S_(60)nanoparticle pseudovirus nanoparticle influenza virus influenza vaccine HEMAGGLUTININ NOROVIRUS 
A broadly neutralizing human monoclonal antibody against the hemagglutinin of avian influenza virus H7N9被引量：1
《Chinese Medical Journal》2022年第7期799-805,共7页Jingxin Li Li Zhang Linlin Bao Yuxiao Wang Lin Qiu Jialei Hu Rong Tang Huiyan Yu Jun Shan Yan Li Chuan Qin Fengcai Zhu 
National Natural Science Foundation for Youth,China(No.81501793)。
Background:The new emerging avian influenza A H7N9 virus,causing severe human infection with a mortality rate of around 41%.This study aims to provide a novel treatment option for the prevention and control of H7N9.Me...
关键词：Avian influenza H7N9 Monoclonal antibody Neutralizing activity 
Combined insertion of basic and non-basic amino acids at hemagglutinin cleavage site of highly pathogenic H7N9 virus promotes replication and pathogenicity in chickens and mice
《Virologica Sinica》2022年第1期38-47,共10页Aobaixue Zhou Jiahao Zhang Huanan Li Qiang Xu Yiqun Chen Bo Li Wanying Liu Guanming Su Xingxing Ren Guangjie Lao Baozheng Luo Ming Liao Wenbao Qi 
supported by National Natural Science Foundation of China(31672586 and 31830097);the Key Research and Development Program of Guangdong Province(2019B020218004);Earmarked Found for China Agriculture Research System(CARS-41-G16);Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme(2018,Wenbao Qi);Young Scholars of Yangtze River Scholar Professor Program(2019,Wenbao Qi)
Since mid-2016,the low pathogenic H7N9 influenza virus has evolved into a highly pathogenic(HP)phenotype in China,raising many concerns about public health and poultry industry.The insertion of a“KRTA”motif at hemag...
关键词：H7N9 Highly pathogenic Cleavage site Basic and non-basic amino acids PATHOGENICITY 
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