Status,challenges,and future prospects of stem cell therapy in pelvic floor disorders  

作　　者：Juan Cheng Zhi-Wei Zhao Ji-Rui Wen Ling Wang Li-Wei Huang Yan-Lin Yang Feng-Nian Zhao Jing-Yue Xiao Fei Fang Jiang Wu Ya-Li Miao 

机构地区：[1]Department of Obstetrics and Gynecology,Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE,West China Second University Hospital,West China Campus,Sichuan University,Chengdu 610041,Sichuan Province,China [2]Deep Underground Space Medical Center,West China Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China [3]West China School of Basic Medical Sciences&Forensic Medicine,Sichuan University,Chengdu 610041,Sichuan Province,China [4]West China School of Stomatology Medicine,Sichuan University,Chengdu 610041,Sichuan Province,China [5]West China School of Medicine/West China Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China

出　　处：《World Journal of Clinical Cases》2020年第8期1400-1413,共14页世界临床病例杂志

基　　金：Foundation of Sichuan Provincial Science and Technology Program,No.2019YFH0147 and No.2019YFH0158;Chengdu Technological Innovation Research and Development Project,No.2018-YF05-00195-SN;West China Second University Hospital Xinya Fund,No.kx111;1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University,No.ZYJC18016.

摘　　要：Pelvic floor disorders(PFDs)represent a group of common and frequentlyoccurring diseases that seriously affect the life quality of women,generally including stress urinary incontinence and pelvic organ prolapse.Surgery has been used as a treatment for PFD,but almost 30%of patients require subsequent surgery due to a high incidence of postoperative complications and high recurrence rates.Therefore,investigations of new therapeutic strategies are urgently needed.Stem cells possess strong multi-differentiation,self-renewal,immunomodulation,and angiogenesis abilities and they are able to differentiate into various cell types of pelvic floor tissues and thus provide a potential therapeutic approach for PFD.Recently,various studies using different autologous stem cells have achieved promising results by improving the pelvic ligament and muscle regeneration and conferring the tissue elasticity and strength to the damaged tissue in PFD,as well as reduced inflammatory reactions,collagen deposition,and foreign body reaction.However,with relatively high rates of complications such as bladder stone formation and wound infections,further studies are necessary to investigate the role of stem cells as maintainers of tissue homeostasis and modulators in early interventions including therapies using new stem cell sources,exosomes,and tissueengineering combined with stem cell-based implants,among others.This review describes the types of stem cells and the possible interaction mechanisms in PFD treatment,with the hope of providing more promising stem cell treatment strategies for PFD in the future.

关 键 词：PELVIC floor disorders PELVIC organ PROLAPSE Stress URINARY INCONTINENCE MESENCHYMAL STEM cells STEM cell therapy 

分 类 号：R711.5[医药卫生—妇产科学]