Seroconversion of HBsAG coincides with hepatitis A superinfection: A case report  

作　　者：Claudia Beisel Marylyn M Addo Julian Schulze zur Wiesch 

机构地区：[1]Department of Internal Medicine,Division of Infectious Disease,University Medical Center Hamburg-Eppendorf,Hamburg 20251,Germany [2]German Center for Infection Research,Hamburg 20251,Germany

出　　处：《World Journal of Clinical Cases》2020年第9期1651-1655,共5页世界临床病例杂志

摘　　要：BACKGROUND Hepatitis B virus(HBV)is a hepatotropic virus that can cause acute and chronic liver damage.According to the world health organization 257 million people are infected with chronic HBV infection worldwide.Super-infection with other hepadnaviruses,including hepatitis A virus(HAV),hepatitis C virus,hepatitis D virus,and hepatitis E virus is associated with increased risk of acute liver failure in patients with chronic HBV.CASE SUMMARY Here,we report a case of a 47-year old male patient with HBV-related compensated Child A cirrhosis,who presented with general fatigue,malaise and laboratory signs of acute hepatitis.Although the patient was regularly seen at a specialized university liver unit,the HAV vaccination status was unclear.Acute HAV super-infection was diagnosed by positive serological and polymerase chain reaction analysis.Following acute HAV super-infection,spontaneous HBsAg elimination and development of an anti-HBs titer were observed.CONCLUSION This case illustrates the importance of carefully checking the vaccination status.In our patient,unspecific immunological responses to HAV led to functional cure of HBV.

关 键 词：Chronic HEPATITIS B INFECTION Liver cirrhosis Acute HEPATITIS A INFECTION HBSAG clearance Functional CURE Case report 

分 类 号：R512.61[医药卫生—内科学]