Granulocyte colony-stimulating factor-producing squamous cell carcinoma of the tongue exhibiting characteristic fluorine-18 deoxyglucose accumulation on positron emission tomography–computed tomography: A case report  

作　　者：Hiroaki Shimamoto Yuka Hirota Yoshihisa Kashima Naoya Kinoshita Misaki Yokokawa Tohru Ikeda Hiroyuki Harada 

机构地区：[1]Oral and Maxillofacial Surgery,Graduate School of Medical and Dental Sciences,Tokyo Medical and Dental University,Tokyo 113-8549,Japan [2]Human Pathology,Graduate School of Medical and Dental Sciences,Tokyo Medical and Dental University,Tokyo 113-8549,Japan [3]Oral Pathology,Graduate School of Medical and Dental Sciences,Tokyo Medical and Dental University,Tokyo 113-8549,Japan

出　　处：《World Journal of Clinical Cases》2020年第9期1666-1673,共8页世界临床病例杂志

摘　　要：BACKGROUND Granulocyte colony-stimulating factor(G-CSF)is a cytokine produced in inflammatory environments that induces differentiation and proliferation of neutrophils in bone marrow.We report a rare case of aggressive G-CSFproducing squamous cell carcinoma of the tongue exhibiting fluorine-18 deoxyglucose(FDG)accumulation in primary lesion,metastatic lymph nodes,spleen,and bone marrow on positron emission tomography–computed tomography(PET/CT).CASE SUMMARY We report a 58-year-old female with a rapid enlarged lingual mass with partial necrosis.Blood test results from the initial examination revealed a leukocyte count of 21380/μL.On PET/CT,extensive FDG accumulation was observed in the tongue and bilateral cervical lymph nodes,with elevated FDG accumulation in the spleen and bone marrow although no distant metastases were observed.We performed partial glossectomy and bilateral neck dissection.Immunohistochemical staining with G-CSF antibodies on biopsy specimen and resected samples revealed that both specimens were G-CSF positive.This is a rare case of G-CSF producing tongue carcinoma with elevated FDG accumulation in the spleen and bone marrow.CONCLUSION In patients with the tongue cancer and hyperleukocytosis,where FDG accumulations in the spleen and bone marrow are observed using PET/CT and when these accumulations are not caused by metastasis,G-CSF-producing tumors,with associated poor prognosis,should be considered.

关 键 词：TONGUE cancer GRANULOCYTE colony-stimulating factor Hyperlukocytosis POSITRON emission tomograph Case report 

分 类 号：R739.86[医药卫生—肿瘤] R730.44[医药卫生—临床医学]