miR-19a-3p在前列腺癌细胞侵袭和迁移中的作用  

The Role of miR-19a-3p in the Invasion and Migration of Prostate Cancer Cells

作　　者：叶明佶 戴涛 谢宇[1] Ye Mingji;Dai Tao;Xie Yu(Hunan Cancer Hospital,Changsha,410013)

机构地区：[1]湖南省肿瘤医院,长沙410013

出　　处：《基因组学与应用生物学》2020年第2期822-829,共8页Genomics and Applied Biology

摘　　要：miR-19a-3p通过多种机制调节癌细胞的增殖和转移,然而,miR-19a-3p在前列腺癌转移中的生物学作用和机制尚不清楚。本研究旨在考察mir-19a-3p在前列腺癌中的表达情况,及其对细胞侵袭和迁移的影响。本研究发现,miR-19a-3p在骨转移性前列腺癌组织和前列腺癌细胞中明显下调。上调miR-19a-3p可显著抑制前列腺癌细胞的侵袭和迁移。然而,下调miR-19a-3p则会逆转上述变化。此外,本研究还发现miR-19a-3p通过靶向TGF-β信号传导的下游效应物SMAD2来抑制前列腺癌细胞中TGF-β信号传导的活性,从而抑制前列腺癌细胞的侵袭和迁移。因此,本研究表明mir-19a-3p与前列腺癌的发生发展密切相关,mir-19a-3p有望成为前列腺癌的新治疗靶点及生物标志物。miR-19 a-3 p regulates the proliferation and metastasis of cancer cells through various mechanisms.However,the biological role and mechanism of miR-19 a-3 p in prostate cancer metastasis remains unclear.This study was designed to investigate the expression of mir-19 a-3 p in prostate cancer and its effects on cell invasion and migration.This study found that miR-19 a-3 p was significantly down-regulated in bone metastatic prostate cancer tissues and prostate cancer cells.Up-regulation of miR-19 a-3 p significantly inhibited the invasion and migration of prostate cancer cells.However,down-regulation of miR-19 a-3 p reversed these changes.In addition,this study also found that miR-19 a-3 p inhibited the activity of TGF-βsignaling in prostate cancer cells by targeting the downstream effector SMAD2 of TGF-βsignaling,thereby inhibiting the invasion and migration of prostate cancer cells.Therefore,this study shows that mir-19 a-3 p is closely related to the development of prostate cancer,and mir-19 a-3 p is expected to become a new therapeutic target and biomarker for prostate cancer.

关 键 词：前列腺癌 微小RNA miR-19a-3p 侵袭 迁移 

分 类 号：R737.25[医药卫生—肿瘤]