热疗联合放化疗治疗局部晚期非小细胞肺癌的临床效果  

Clinical effect of hyperthermia combined with chemoradiotherapy in the treatment of locally advanced non-small cell lung cancer

作　　者：赵凯[1] 王志武[1] 杨俊泉[1] ZHAO Kai;WANG Zhiwu;YANG Junquan(The First Department of Chemoradiotherapy,Tangshan People's Hospital,Hebei Province,Tangshan 063000,China)

机构地区：[1]唐山市人民医院放化疗一科,河北唐山063000

出　　处：《中国医药导报》2020年第11期84-87,共4页China Medical Herald

基　　金：国家自然科学基金资助项目(81603475)。

摘　　要：目的观察热疗联合放化疗治疗局部晚期非小细胞肺癌(NSCLC)的临床效果及其对生存的影响。方法选取2015年1月~2017年1月唐山市人民医院放化疗科收治的110例局部晚期NSCLC患者,采用随机数字表法将其分为观察组和对照组,每组55例。观察组给予同步放化疗联合热疗治疗,对照组给予同步放化疗治疗。比较两组近期疗效、毒副作用发生情况以及远期生存情况。结果观察组有效率明显高于对照组,差异有统计学意义(P<0.05)。两组患者放射性食管炎、放射性肺炎、骨髓抑制、放射性皮炎发生率比较,差异无统计学意义(P>0.05);观察组2年累积生存率高于对照组,差异有统计学意义(P>0.05)。结论热疗联合放化疗治疗局部晚期NSCLC的近期效果确切,与单纯放化疗比较提高了生存率。Objective To observe the clinical effect of hyperthermia combined with radiotherapy and chemotherapy in the treatment of locally advanced non-small cell lung cancer(NSCLC)and its effect on survival.Methods A total of 110 patients with locally advanced NSCLC admitted to the Chemoradiot Department of Tangshan People's Hospital from January 2015 to January 2017 were selected.They were divided into the observation group and the control group by random number table method,with 55 cases in each group.The observation group received synchronous radiotherapy and chemotherapy combined with hyperthermia,and the control group received synchronous radiotherapy and chemotherapy.The short-term efficacy,incidence of toxic and side effects and long-term survival of the two groups were compared.Results The effective rate of the observation group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of radiation esophagitis,radiation pneumonia,myelosuppression and radiation dermatitis between the two groups(P>0.05).The 2-year cumulative survival rate of the observation group was higher than that of the control group,and the difference was statistically significant(P>0.05).Conclusion The short-term efficacy of hyperthermia combined with radiotherapy and chemotherapy in the treatment of locally advanced NSCLC is accurate,and the survival rate is improved compared with that of radiotherapy and chemotherapy alone.

关 键 词：非小细胞肺癌 放疗 化疗 热疗 

分 类 号：R734.2[医药卫生—肿瘤]