血清胱抑素C、纤维蛋白原和C-反应蛋白水平与颅内动脉瘤发生及破裂的关系  

The relationship between the levels of serum cystatin C,fibrinogen and C-reactive protein and the occurrence and rupture of intracranial aneurysms

作　　者：杨婧[1] 朱金芬[1] 马澜 孟灵[1] Yang Jing;Zhu Jinfen;Ma Lan;Meng Ling(Laboratory Department, the Second Hospital of Lanzhou University, Lanzhou 731000, China)

机构地区：[1]兰州大学第二医院检验科,甘肃兰州731000

出　　处：《临床荟萃》2020年第6期525-527,共3页Clinical Focus

摘　　要：目的探讨血清胱抑素C(serum cystatin C,CysC)、纤维蛋白原(fibrinogen,FBG)和C-反应蛋白(C-reactive protein,CRP)水平与颅内动脉瘤发生及破裂的关系。方法选取颅内动脉瘤患者100例分为破裂组(n=54)和未破裂组(n=46),50例健康体检者为对照组。收集患者血液和脑脊液并检测血清CysC、FBG和CRP的含量。结果颅内动脉瘤患者中饮酒、吸烟、高血压和动脉粥样硬化比例明显高于对照组,且破裂组年龄≥60岁、男性、饮酒、吸烟、糖尿病、高血压及动脉粥样硬化占比更高,差异具有统计学意义(p<0.05)。与对照组相比,颅内动脉瘤患者血液和脑脊液内CysC、FBG和CRP含量显著升高(P<0.05)。结论颅内动脉瘤患者血液和脑脊液内CysC、FBG和CRP含量异常升高,且CysC、FBG和CRP含量与颅内动脉瘤破裂有关。Objective To investigate the relationship between the levels of serum cystatin C(CysC),fibrinogen(FBG)and C-reactive protein(CRP)and the occurrence and rupture of intracranial aneurysms.Methods A total of 100 patients with intracranial aneurysms were divided into the ruptured group(n=54)and the unruptured group(n=46),and 50 healthy people were selected as the control group.Blood and cerebrospinal fluid samples were collected and the levels of serum CysC,FBG and CRP were measured.Results Among patients with intracranial aneurysms,the proportion of drinking,smoking,hypertension and atherosclerosis was significantly higher than that of the control group,and the proportion of age≥60 years old,male,drinking,smoking,diabetes,hypertension and atherosclerosis in the ruptured group were higher(P<0.05).Compared with the control group,the levels of CysC,FBG and CRP in the blood and cerebrospinal fluid of patients with intracranial aneurysms were significantly increased(P<0.05).Conclusion The levels of CysC,FBG and CRP in the blood and cerebrospinal fluid of patients with intracranial aneurysms are increased abnormally,and the levels of CysC,FBG and CRP are related to the rupture of intracranial aneurysms.

关 键 词：颅内动脉瘤 血清胱抑素C 纤维蛋白原 C-反应蛋白 

分 类 号：R743.9[医药卫生—神经病学与精神病学]