Lennox-Gastaut综合征治疗研究进展  

Research Progress of Lennox-Gastaut Syndrome Treatment

作　　者：宫玉哲 王天成[1] GONG Yuzhe;WANG Tiancheng(Department of Epilepsy,the Second Hospital of Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学第二医院癫痫科,兰州730000

出　　处：《医学综述》2020年第9期1802-1807,共6页Medical Recapitulate

基　　金：兰州市人才创新创业项目(2015-RC-25);兰州市城关区科技计划项目(2016-7-19)。

摘　　要：Lennox-Gastaut综合征(LGS)是一种多见于儿童的严重癫痫性脑病,通常预后较差。LGS的治疗以抗癫痫药物(AEDs)为主,目前认为丙戊酸钠、拉莫三嗪和托吡酯为一线治疗用药,左乙拉西坦、卢非酰胺、氯巴占、大麻二酚以及类固醇皮质激素等可作为辅助治疗药物;其他治疗方式包括生酮饮食、迷走神经刺激术、胼胝体切开术以及致痫灶切除手术等。LGS患者常对现有AEDs产生耐药性,而反复的癫痫发作严重降低了患者的智力水平、社会功能和生活质量,因此探索更加有效的治疗方法至关重要。Lennox-Gastaut syndrome( LGS) is a severe epileptic encephalopathy that is more common in children and usually has a worse prognosis. Antiepileptic drugs( AEDs) are the main treatment of LGS,and sodium valproate,lamotrigine and topiramate are currently considered as the first-line treatment drugs. Levetiracetam,rufinamide,clozam,cannabidiol,and corticosteroids can be used as adjuvant drugs. Other treatments include ketogenic diet,vagus nerve stimulation,corpus callosotomy and epileptogenic focus resection. LGS patients often develop resistance to existing AEDs,and repeated epileptic seizures have severely reduced the patient’s intelligence level,social function and quality of life,so it is important to explore more effective treatments.

关 键 词：LENNOX-GASTAUT综合征 抗癫痫药物 生酮饮食 迷走神经刺激术 胼胝体切开术 

分 类 号：R742.1[医药卫生—神经病学与精神病学]