乳腺癌患者改良根治术后切口感染相关因素配对研究  

A paired study on factors related to wound infection in breast cancer patients after modified radical mastectomy

作　　者：林红[1] 孙慧[1] 吴荣华[1] 雷晓婷[1] LIN Hong;SUN Hui;WU Rong-hua;LEI Xiao-ting(Jiangsu Provincial Hospital of TCM,Affiliated Hospital of Nanjing University of TCM,Jiangsu Nanjing 210029,China)

机构地区：[1]江苏省中医院(南京中医药大学附属医院),江苏南京210029

出　　处：《临床医药文献电子杂志》2020年第17期8-10,共3页Electronic Journal of Clinical Medical Literature

摘　　要：目的了解乳腺癌患者改良根治术后切口感染的相关因素,为临床防控提供依据。方法采用回顾性病例对照研究方法,选取2014年1月~2017年12月某三甲中医院乳腺外科乳腺癌患者行改良根治术后切口感染的患者45例,按照1:2配对的方法,筛选出同期同手术方式未感染的患者90例,收集两组患者临床资料,进行相关因素统计分析。结果单因素条件Logistic回归分析显示,住院总天数、术前住院天数、手术时间、ASA评分、术中失血量、术后血糖、术前是否预防性使用抗生素与乳腺癌患者改良根治术后切口感染的发生相关(P<0.05)。多因素分析结果显示手术时间(OR=1.449,95%CI=1.011~2.076)、术中失血量(OR=2.448,95%CI=1.307~4.585)是乳腺癌患者改良根治术后切口感染的独立危险因素,而术前预防性使用抗菌药物(OR=0.112,95%CI=0.016~0.770)是其保护因素。结论乳腺癌患者改良根治术后发生切口感染是多种因素共同作用的结果,临床应根据患者的个体差异采取不同的应对措施,减少切口感染的发生。Objective To understand the related factors of wound infection after modified radical mastectomy in breast cancer patients,and to provide evidence for clinical prevention and control.Methods A retrospective case control study was used,and 45 cases of breast cancer patients were selected in the department of the traditional Chinese medicine of hospital in 2014-2017,and 90 cases of uninfected patients in the same period as the control group according to the method of 1:2 matching,we’ll analyse the clinical data which was collected from the two group.Results The analysis results show that the total days of hospitalization,the number of days before the operation,the time of operation,the ASA score,the blood loss,the blood glucose after the operation,and the preventive use of antibiotics before the operation,all of those were related to the incidence of wound infection after modified radical mastectomy in breast cancer(P<0.05).The results of multifactor analysis showed that the time of operation(OR=1.449,95%CI=1.011~2.076)、the amount of blood loss(OR=2.448,95%CI=1.307~4.585)were independent risk factors for the wound infection after modified radical mastectomy in breast cancer patients,and the preventive use of antibiotics before the operation was the protective factor.Conclusion The infection of breast cancer patients is that multiple facts play a role.We should take measures to reduce the incidence of wound infection according to the individual difference.

关 键 词：乳腺癌 改良根治术 切口感染 相关因素 

分 类 号：R737.9[医药卫生—肿瘤]