低温合成三氯蔗糖-6-苯甲酸酯及其工艺优化  

Low temperature synthesis and process optimization of sucralose-6-benzoate

作　　者：刘俊杰 LIU Jun-jie(Guangye L&P Food Ingredient Co.,Ltd.,Guangzhou 510308)

机构地区：[1]广东广业清怡食品科技有限公司,广州510308

出　　处：《中国食品添加剂》2020年第4期85-88,共4页China Food Additives

摘　　要：以蔗糖-6-苯甲酸酯为原料,建立了一种低温氯代合成三氯蔗糖-6-苯甲酸酯的方法。探讨了氯代剂的用量、助溶剂的用量、反应温度、反应时间和溶剂的用量等因素对反应的影响。最终确定了最优条件为n(vilsmeier试剂):n(蔗糖-6-苯甲酸酯)=9∶1、反应温度为100℃、反应时间11h、V(DMF):m(蔗糖-6-苯甲酸酯)=2∶1(mL∶g)、V(DMF)∶V(DMAc)=5∶1。在此条件下,可在低温合成三氯蔗糖-6-苯甲酸酯,且三氯蔗糖-6-苯甲酸酯的得率达68%。A method for the synthesis of sucralose-6-benzoate by chlorination at low temperature was established using sucrose-6-benzoates as raw material.The effects of the molar ratio of raw material,reaction time,reaction temperature,and cosolvent dosage on chlorination were investigated.The results showed that the molar ratio of Vilsmeier reagent to sucrose-6-benzoate was 9∶1 and volume ratio of 1,1,2-trechloroethane to N,N-Dimethylformamide was 5∶1.This chlorination reaction was reacted at 100℃for 11h.Under these conditions sucralose-6-benzoate can be synthesized at low temperature,and the yield of sucralose-6-benzoate was 68%.

关 键 词：蔗糖-6-苯甲酸酯 三氯蔗糖-6-苯甲酸酯 氯代 vilsmeier试剂 

分 类 号：TS245.9[轻工技术与工程—制糖工程] TS246.4[轻工技术与工程—食品科学与工程]