Regulatory mechanisms of endometrial decidualization and pregnancy-related diseases  

作　　者：Yifei Sang Yanhong Li Ling Xu Dajin Li Meirong Du 

机构地区：[1]NHC Key Lab of Reproduction Regulation(Shanghai Institute of Planned Parenthood Research),Hospital of Obstetrics and Gynecology,Fudan University Shanghai Medical College,Shanghai 200011,China [2]Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases,Shanghai 200011,China [3]Department of Obstetrics and Gyn ecology,Guangzhou First Peoples Hospital,School of Medicine,South China University of Technology,Guangzhou 510180,China

出　　处：《Acta Biochimica et Biophysica Sinica》2020年第2期105-115,共11页生物化学与生物物理学报（英文版）

摘　　要：Endometrial decidualization is one of the earlest changes by which the uterus adapts to pregnancy.During this period,the endometrium undergoes complex changes in its biochemistry,physiology,and function at various levels,providing a suitable microenvironment for embryo implantation and development.Favorable decidualization lays an essential foundation for subsequent gestation,without which pregnancy failure or pregnancy complications may occur.The interaction between pregnancy-related hormones and cytokines produced by embryonic and uterine cells is known to be essential for decidualization,in which some transcription factors also play pivotal roles.Increasing evidence has revealed the importance of metabolism in regulating decidualization.Here,we summarize and discuss these crucial elements in decidualization and the relationship between decidualization and pregnancy complications.A better comprehension of these issues should help to improve the prediction of pregnancy outcomes and the use of appropriate intervention.

关 键 词：DECIDUALIZATION regulatory mechanism RECURRENT implantation failure RECURRENT SPONTANEOUS ABORTION PREECLAMPSIA 

分 类 号：R71[医药卫生—妇产科学]