乳腺肌样错构瘤2例临床病理观察  

Clinicopathologic features of breast myoid hamartoma:report of two cases

作　　者：张彤 朱晓云 王丽华 饶晓松 ZHANG Tong;ZHU Xiao-yun;WANG Li-hua;RAO Xiao-song(Department of Pathology,Peking University International Hospital,Beijing 102206,China)

机构地区：[1]北京大学国际医院病理科,北京102206

出　　处：《诊断病理学杂志》2020年第2期94-96,100,共4页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨乳腺肌样错构瘤(MH)的临床及病理特征,加强病理医生对MH的认识。方法收集乳腺肌样错构瘤2例,观察其大体、镜下特点及免疫表型特点。结果2例发病年龄分别为21岁、29岁。肿瘤直径分别为2 cm、1.9 cm,肿瘤1例边界清楚,1例边界不清。肿瘤均由不同比例的乳腺腺泡、导管、纤维间质、脂肪组织及肌样细胞束组成。肌样细胞平行或交叉呈束状排列,形成灶性的平滑肌瘤样形态,散在分布于纤维间质之间,部分区域穿插入小叶腺泡间。2例肌样成分均强阳性表达SMA、Desmin和Caldesmon。结论MH是乳腺错构瘤的少见亚型,以表达平滑肌标记的平滑肌样细胞束为典型特征,易发生漏诊、误诊,诊断时应充分结合临床病史及镜下、免疫组化特点。Objective To discuss the clinicopathologic features of myoid harmatoma(MH)to strengthen the understanding of the pathologists to MH.Methods The clinical and pathological data of 2 cases of MH were collected,and the gross,microscopic and the immunohistochemical characteristics were observed.Results Two patients ranged in age from 21 to 29 years.Grossly,the tumors ranged from 1.9 cm to 2.0 cm in size;one case was sharply demarcated,and another case was poorly defined.The tumors were composed of different proportions of breast alveolar,ducts,fibrous,fatty and myoid bundles.The myoid cells were ranged in bundles parallel or intersected,scattered in the interfibrillar substance and formed focal leiomyomatoid pattern.Part of the myoid bundles inserted into the glandular bubbles.Immunohistochemically,the myoid cells were positive for SMA,desmin and caldesmon.Conclusins MH is a rare subtype of mammary hamartoma,and is characterized by the presence of myoid cell bundles showing smooth muscle differentiation.Misdiagnosis and missed diagnosis are easy to happen.The clinical data,microscopic and immunohistochemical features should be combined in the diagnosis.

关 键 词：乳腺错构瘤 乳腺肌样错构瘤 肌样分化 鉴别诊断 

分 类 号：R737.9[医药卫生—肿瘤]