杭州3865例男性患者人乳头瘤状病毒检测结果分析  

Analysis of detection results of human papilloma virus in 3865 male patients in Hangzhou

作　　者：陈建萍[1] 滕勇[1] 李新征[1] 陈宝炳[1] 钟春燕[1] CHEN Jian-ping;TENG Yong;LI Xin-zheng;CHEN Bao-bing;ZHONG Chun-yan(Clinical Laboratory,the 3rd People's Hospital of Hangzhou,Hangzhou,Zhejiang 310006,China)

机构地区：[1]杭州市第三人民医院检验科,浙江杭州310006

出　　处：《中国卫生检验杂志》2020年第7期888-890,896,共4页Chinese Journal of Health Laboratory Technology

摘　　要：目的了解本院性病门诊及泌尿外科门诊就诊的男性患者肛门生殖器人乳头瘤状病毒(HPV)的感染情况及其基因型的分布。方法采用PCR体外扩增和DNA反向杂交相结合的HPV基因分型术对采自肛门生殖器及其皮肤患处的分泌物进行23种基因型的检测。结果3865例男性患者中HPV感染者有2019例,感染率为52.24%。其中单一亚型感染者为1124例,占29.08%;二重亚型感染者为485例,占12.55%;三重亚型感染者为223例,占5.77%;四重亚型感染者为124例,占3.21%;五重及以上感染者为63例,占1.63%。不同年龄组人群的HPV感染比较差异有统计学意义(χ2=35.902,P<0.01)。低危型亚型检出率排前两位的为HPV6型、HPV11型,各占35.71%、25.41%;高危型亚型检出率排前两位的为HPV52型、HPV16型,占13.62%、10.45%。结论杭州男性肛门生殖器HPV感染率较高,各年龄段人员均易感染,感染情况以单一亚型感染为主,感染亚型以低危型HPV6型、HPV11型占优势,高危型以HPV52型、HPV16型相对占优。Objective To investigate the infection of human papillomavirus(HPV)in male patients with venereal disease and urology clinic in our hospital and its genotype distribution.Methods Using PCR in vitro amplification combined with DNA reverse hybridization,23 genotypes were detected by HPV genotyping.Results Among the 3865 male patients,2019 patients were infected with HPV,and the infection rate was 52.24%.Among them,there were 1124 cases of single subtype infection,accounting for 29.08%;there were 485 cases of double subtype infection,accounting for 12.55%;there were 223 cases of triple subtype infection,accounting for 5.77%;124 cases of quadruple subtype infection accounted for 3.21%;the number of patients with five or more infections was 63,accounting for 1.63%.The differences in HPV infection among different age groups are statistically significant(χ2=35.902,P<0.01).The top two low-risk subtypes are HPV6 and HPV11,each accounting for 35.71%and 25.41%;the top two high-risk subtypes were HPV52 and HPV16,accounting for 13.62%and 10.45%.Conclusion The infection rate of male anal genital HPV in Hangzhou is high,and people of all ages are prone to infection.The infection situation is dominated by a single subtype infection.The infection subtypes are low-risk HPV6 and HPV11,and HPV52 and HPV16 are the dominant high-risk types.

关 键 词：男性 感染 人乳头瘤状病毒 基因型 

分 类 号：R737.33[医药卫生—肿瘤]