精细化操作对注射用紫杉醇(白蛋白结合型)静脉输液配制结局改善的影响  

Effect of fine operation on improvement of preparation outcome of paclitaxel(albumin-binding)intravenous infusion for injection

作　　者：侯欣美[1] 孙雪松[2] 袁偲偲[1] 李瑞莲 杜博冉[1] Hou Xinmei;Sun Xuesong;Yuan Sisi;Li Ruilian;Du Boran(Department of Pharmacy,Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing 100006,China;Department of Gynecologic oncology,Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing 100006,China)

机构地区：[1]首都医科大学附属北京妇产医院药事部,100006 [2]首都医科大学附属北京妇产医院妇科肿瘤科,100006

出　　处：《中国实用护理杂志》2020年第14期1092-1096,共5页Chinese Journal of Practical Nursing

摘　　要：目的探究实施精细化操作对注射用紫杉醇(白蛋白结合型)静脉输液配制结局改善的影响及必要性。方法对注射用紫杉醇(白蛋白结合型)说明书中关于配制方法方面未明确说明的内容进行详细的精细化操作制定。制订的注射用紫杉醇(白蛋白结合型)精细化配制操作主要包含溶媒与药品混匀方法:注射器进针长度,溶媒注入速度,药品等待溶解时状态,翻转药品西林瓶的摇动速度4个具体细节;药品西林瓶中溶解的药液抽出并注入100 ml无菌空0.9%氯化钠注射液瓶中方法:包括药液重新注入100 ml无菌空0.9%氯化钠注射液瓶中的速度,恢复输液瓶内外气压平衡2个具体细节。通过对比精细化操作实施前后,配制药液中泡沫产生的2种情况及配制时间3个指标,评价精细化操作对配制注射用紫杉醇(白蛋白结合型)的实施效果。结果精细化操作实施前后,药品西林瓶中泡沫产生率从28.57%(10/35)降至12.50%(12/96),差异有统计学意义(χ2值为4.471,P=0.029);混匀后的药液从药品西林瓶抽入100 ml无菌空0.9%氯化钠注射液瓶中泡沫产生率从46.15%(6/13)降至9.09%(3/33),差异有统计学意义(χ2值为8.14,P=0.004);精细化操作实施后单支药品的配制时间平均降低3.37 min,差异有统计学意义(t值为79.744,P<0.05)。结论注射用紫杉醇(白蛋白结合型)精细化操作的配制方法可操作性强,安全可靠。实施后可有效减少药品西林瓶内及输液瓶内泡沫的产生,改善药物配制稳定性,缩短配制时间,保证患者安全、及时、有效用药。Objective To investigate the effect and necessity of fine operation on the improvement of the preparation outcome of paclitaxel(albumin-binding)intravenous infusion for injection.Methods The detailed refinement of the preparation method in the specification of paclitaxel(albumin-binding)for injection was developed.The fine operation of paclitaxel(albumin-binding)for injection mainly consists of two parts:The mixing method of solvent and drug:including syringe needle length into drug vial,solvent injection speed,state of drug waiting for dissolution,and the shaking speed of the drug vial.The method of extracting the dissolved liquid in the drug vial and injecting it into a 100 ml sterile empty 0.9%sodium chloride injection bottle:including the speed of refilling the 100 ml sterile empty 0.9%sodium chloride injection bottle,and restoring the pressure balance inside and outside the infusion bottle.The effect of fine operation on the preparation of paclitaxel(albumin-binding)for injection was evaluated by comparing the production of foam and the preparation time before and after the implementation of fine operation.Results Before and after the implementation of fine operation,the foaming rate of the foam in the drug vial decreased from 28.57%(10/35)to 12.50%(12/96),the difference was statistically significant(χ2 value was 4.471,P=0.029);and the foaming rate of the mixed liquid from the drug vial into the 100 ml sterile empty 0.9%sodium chloride injection bottle decreased from 46.15%(6/13)to 9.09%(3/33),the difference was statistically significant(χ2 value was 8.140,P value was 0.004);and the preparation time of single drug was reduced by 3.37 minutes after the implementation of fine operation,the difference was statistically significant(t value was 79.744,P<0.05).Conclusion The preparation method of fine operation of paclitaxel(albumin-binding)for injection is operable,safe and reliable.After implementation,it can effectively reduce the production of foam in the drug vial and infusion bottle,improve the stability o

关 键 词：精细化操作 注射用紫杉醇(白蛋白结合型) 化疗输液配制 药液泡沫 

分 类 号：R[医药卫生]