TRAF3与非酒精性脂肪性肝病的相关性  

Association between TRAF3 and nonalcoholic fatty liver disease

作　　者：胡丹丹 沈琼[1] 吴英[1] 高贝贝 曹梦蝶 从相国 俞岭 陈蕾[1] Hu Dandan;Shen Qiong;Wu Ying;Gao Beibei;Cao Mengdie;Cong Xiangguo;Yu Ling;Chen Lei(Department of Endocrinology,Suzhou Municipal Hospital,Suzhou 215002,China)

机构地区：[1]苏州市立医院本部内分泌科,215002

出　　处：《国际内分泌代谢杂志》2020年第2期134-137,共4页International Journal of Endocrinology and Metabolism

摘　　要：肿瘤坏死因子相关受体因子(TRAF)家族包括7个成员(TRAF1~TRAF7),在多种病理生理过程中发挥信号调节作用。其中,TRAF3是第一个确定与CD40胞质域相互作用的蛋白。近期研究表明,TRAF3作为一种新型代谢调控因子,参与肝脏脂代谢的调节,可促进肝脏脂质的聚集、引起肝细胞炎性反应的发生、促进肝细胞胰岛素抵抗。TRAF3可能成为治疗非酒精性脂肪性肝病的新靶点。Tumor necrosis factor receptor(TNFR)-associated factor(TRAF)family consists of seven members(TRAF1-TRAF7)that can function as signaling adaptors in various pathophysiologic processes.Among TRAF members,TRAF3 was first identified as a protein interacting with CD40 cytoplasmic domain.Recent studies have shown that TRAF3,a new metabolic regulator,participated in the regulation of liver lipid metabolism,including promoting the accumulation of liver lipid,causing the occurrence of inflammatory response of hepatocytes,and promoting insulin resistance of hepatocytes.TRAF3 will become a new target for the treatment of NAFLD.

关 键 词：肿瘤坏死因子相关受体因子3 非酒精性脂肪性肝病 脂代谢 

分 类 号：R575[医药卫生—消化系统]