人脐血单个核细胞移植治疗血管性痴呆患者脑血流及炎性细胞因子的影响  

Effects of human umbilical cord blood mononuclear cell transplantation on cerebral blood flow and serum inflammatory cytokines in patients with vascular dementia

作　　者：李茹 娄满[1] 苏宁[1] 英俊岐[1] 高春燕[1] Li Ru;Lou Man;Su Ning;Ying Junqi;Gao Chunyan(Department of Geriatrics,the Hengshui Harrison International Peace Hospital,Hebei 053000,China)

机构地区：[1]衡水市哈励逊国际和平医院老年病一科,河北053000

出　　处：《脑与神经疾病杂志》2020年第5期289-292,共4页Journal of Brain and Nervous Diseases

基　　金：2018年河北省医学科学研究重点课题计划(20181602)。

摘　　要：目的分析人脐血单个核细胞移植治疗血管性痴呆(VD)患者脑血流及血清炎性细胞因子的影响。方法选取2013年5月至2016年01月期间,因VD于衡水市哈励逊国际和平医院老年病科进行治疗的104例患者作为研究对象,采用随机数字表法将所有患者分为观察组与对照组,其中对照组采用尼莫地平予以口服治疗;观察组采用人脐血单个核细胞移植治疗。对比两组不同治疗方案下神经功能状态(美国国立卫生研究院卒中量表NIHSS、简易智能精神状态检查量表MMSE)、生活能力(ADL)、脑血流及炎性细胞因子变化情况的差异。结果观察组NIHSS评分明显低于对照组,MMSE及ADL评分明显高于对照组(P<0.05);观察组MCA、ACA、PCA、VA及BA血流速度均明显高于对照组(P<0.05);观察组CRP、IL-6及TNF-α等各项炎性因子指标水平均明显低于对照组(P<0.05)。结论人脐血单个核细胞移植在VD临床治疗中的应用可有效改善患者神经功能状况,加快脑部血流循环,降低炎性细胞因子水平,有益于临床应用。Objective To analyze the effect of human umbilical cord blood mononuclear cell transplantation on cerebral blood flow and serum inflammatory cytokines in patients with vascular dementia(VD).Methods 104 patients with VD who were treated in geriatrics department of Harrison International Peace Hospital in Hengshui City from May 2013 to January 2016 were selected as the research objects.All patients were divided into observation group and control group by random number table method.The control group was treated with nimodipine orally;the observation group was treated with nimodipine orally.Human umbilical cord blood mononuclear cell transplantation was used.The changes of neurological function(NIHSS,MMSE,ADL),cerebral blood flow and inflammatory cytokines were compared between the two groups.Results The NIHSS score of the observation group was significantly lower than that of the control group,and the scores of MMSE and ADL were significantly higher than those of the control group(P<0.05);the blood flow velocities of MCA,ACA,PCA,VA and BA in the observation group were significantly higher than those in the control group(P<0.05);the levels of CRP,IL-6 and TNF-ɑin the observation group were significantly lower than those in the control group(P<0.05).Conclusion The application of human umbilical cord blood mononuclear cells transplantation in the clinical treatment of VD can effectively improve the neurological function of patients,speed up cerebral blood circulation,and reduce the levels of various inflammatory cytokines.The clinical application value is significant.

关 键 词：人脐血单个核细胞 移植治疗 血管性痴呆 脑血流 炎性细胞因子 

分 类 号：R743.32[医药卫生—神经病学与精神病学]