Stomatocyte structural color-barcode micromotors for multiplex assays  

作　　者：Lijun Cai Huan Wang Yunru Yu Feika Bian Yu Wang Keqing Shi Fangfu Ye Yuanjin Zhao 

机构地区：[1]Precision Medicine Center Laboratory,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325035,China [2]Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou 325001,China [3]State Key Laboratory of Bioelectronics,School of Biological Science and Medical Engineering,Southeast University,Nanjing 210096,China [4]Beijing National Laboratory for Condensed Matter Physics,Institute of Physics,Chinese Academy of Sciences,Beijing 100190,China

出　　处：《National Science Review》2020年第3期644-651,共8页国家科学评论（英文版）

基　　金：the National Natural Science Foundation of China(61927805 and 11774394);the joint funding of the National Natural Science Foundation of China and China Academy of Engineering Physics(NSAF)(U1530260);the Natural Science Foundation of Jiangsu(BE2018707);the Scientific Research Foundation of Southeast University;the K.C.Wong Education Foundation;the Postdoctoral Science Foundation of China(2019 M653061).

摘　　要：Artificial micromotors have a demonstrated value in the biomedical area.Attempts to develop this technology tend to impart micromotors with novel functions to improve the values.Herein,we present novel structural color-barcode micromotors for the multiplex assays.We found that,by rapidly extracting solvent and assembling monodispersed nanoparticles in droplets,it could form stomatocyte colloidal crystal clusters,which not only showed striking structural colors and characteristic reflection peaks due to their ordered nanoparticles arrangement,but also provided effective cavities for the integration of functional elements.Thus,the micromotors with catalysts or magnetic elements in their cavities,as well as with the corresponding structural color coding,could be achieved by using the platinum and ferric oxide dispersed pre-gel to fill and duplicate the stomatocyte colloidal crystal clusters.We have demonstrated that the self-movement of these structural color-barcode micromotors could efficiently accelerate the mixing speed of the detection sample and greatly increase the probe-target interactions towards faster and more sensitive single or multiplex detection,and the magnetism of these barcode micromotors enables the flexible collection of the micromotors,which could facilitate the detection processes.These features make the stomatocyte structural color-barcode micromotors ideal for biomedical applications.

关 键 词：structural color MICROMOTOR sensor PHOTONIC crystal multiplex ASSAY 

分 类 号：R318[医药卫生—生物医学工程]