对甲氧基苯甲酸的合成工艺研究  

Study on Synthetic Process of p-Methoxybenzoic Acid

作　　者：鞠志宇[1] 傅收 贺医林 马巧丽 许志红[1] 吴长增[1] JU Zhiyu;FU Shou;HE Yilin;MA Qiaoli;XU Zhihong;WU Changzeng(College of Chemistry and Chemical Engineering,Xuchang University,Xuchang 461000,China)

机构地区：[1]许昌学院化学化工学院,河南许昌461000

出　　处：《许昌学院学报》2020年第2期65-68,共4页Journal of Xuchang University

基　　金：国家自然科学基金(21702178);河南省高校科技创新人才计划(15HASTIT002);河南省科技计划项目(182102311108)。

摘　　要：以对羟基苯甲酸为起始原料,采用一锅法合成工艺,考察了氢氧化钠、硫酸二甲酯、反应温度和反应时间对反应产率的影响.最佳反应条件为:反应温度为40℃,滴加1 h后继续反应1 h,对羟基苯甲酸、硫酸二甲酯和NaOH的物质的量比为1∶1.5∶3.0,收率达94.0%.其结构通过1H NMR确证.The synthetic process of p-methoxybenzoic acid was studied by one pot process method of 4-hydroxybenzoic acid and dimethyl sulfate.The effects of various technical parameters,such as NaOH and dimethylmonosulfate agent dosage,reaction temperature and time were investigated by single factor method.And finally a product yield of 94.0% could be achieved under the conditions as follows:the equivalent molar ratio of 4-hydroxybenzoic acid to NaOH and dimethylmonosulfate was 1∶3.0∶1.5,reaction temperature,drip time and reaction time were 40 ℃,1 h and 1 h,respectively.Its structure was characterized by 1H NMR.

关 键 词：对甲氧基苯甲酸 合成 一锅法 

分 类 号：O634.51[理学—高分子化学]