局部进展期胰腺癌纳米刀消融术后并发症分析  

Complications of nano-knife ablation on locally advanced pancreatic cancer

作　　者：仝昊 李晓勇[1] 陈艳军[1] 程冰冰[1] 陈升阳[1] 胡水全 苏东朝 Tong Hao;Li Xiaoyong;Chen Yanjun;Cheng Bingbing;Chen Shengyang;Hu Shuiquan;Su Dongzhao(Department of Hepatobiliary Pancreas Surgery,the Fifth Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第五附属医院肝胆胰腺外科,450052

出　　处：《中华肝胆外科杂志》2020年第4期270-273,共4页Chinese Journal of Hepatobiliary Surgery

摘　　要：目的分析局部进展期胰腺癌不可逆电穿孔(纳米刀)消融术后并发症发生情况,探讨其发生原因及相关治疗方式。方法回顾性收集2016年1月至2019年3月于郑州大学第五附属医院行纳米刀消融术治疗的36例局部进展期胰腺癌患者的临床资料,统计术后并发症种类及发生率,按照Clavien-Dindo分级标准对并发症进行分级,评估相关并发症严重程度。结果共有15例(41.7%)患者出现不同程度的并发症,包括脾梗死、房颤、门静脉血栓、胰瘘、假性动脉瘤、消化道出血、肝脓肿及重症胰腺炎,其中Ⅲ级及以上并发症患者6例(16.7%),3例(8.3%)Ⅲ级并发症患者于术后3个月因上消化道出血死亡。结论纳米刀消融后均有可能发生各类并发症。术后消化道及腹腔出血为其主要致死原因。采用合理的检查及治疗方法可有效地减少并发症的发生。Objective To study the complications of irreversible electroporation(nano-knife)ablation on locally advanced pancreatic cancer,and to analyse the causes of complications and related treatment.Methods The clinical data of 36 patients with locally advanced pancreatic cancer treated with nano-knife ablation at the Fifth Affiliated Hospital of Zhengzhou University from January 2016 to March 2019 were studied retrospectively.The types and incidence of postoperative complications were analyzed.The complications were classified according to the Clavien-Dindo classification,and the severity of the complications was evaluated.Results There were 15 patients(41.7%)who developed various degrees of complications,including splenic infarction,atrial fibrillation,portal vein thrombosis,pancreatic fistula,pseudoaneurysm,gastrointestinal bleeding,liver abscess and severe pancreatitis.Among them,6 patients(16.7%)had grade III complication or above.Three(8.3%)patients with gradeⅢcomplications died of upper gastrointestinal bleeding 3 months after operation.Conclusions Various complications might occur after nano-knife ablation,with postoperative gastrointestinal and abdominal bleeding being the main complications which resulted in death.Measures which can effectively reduce occurrence of complications need to be studied.

关 键 词：胰腺肿瘤 纳米刀 并发症 

分 类 号：R735[医药卫生—肿瘤]