膈下逐瘀汤治疗中晚期肝癌精准TACE术后临床研究  

Clinical Study on Gexia Zhuyu Tang for Advanced Liver Cancer after Precise TACE

作　　者：沈灵娜 楼晓军 刘军[1] 徐瑾[1] SHEN Lingna;LOU Xiaojun;LIU Jun;XU Jin

机构地区：[1]浙江中医药大学附属嘉兴市中医院,浙江嘉兴314001

出　　处：《新中医》2020年第7期44-47,共4页New Chinese Medicine

基　　金：嘉兴市科技计划项目(2016AY23074)。

摘　　要：目的:观察膈下逐瘀汤对中晚期肝癌精准肝动脉化疗栓塞术(TACE)后肝功能损害和临床不良反应的改善作用。方法:将60例中晚期肝癌患者按随机数字表法分为观察组和对照组各30例。对照组行精准TACE术后给予西药护肝治疗,观察组在对照组基础上加用膈下逐瘀汤口服,观察2组治疗后肝功能指标及不良反应发生率。结果:术前,2组丙氨酸氨基转移酶(ALT)、草氨酸氨基转移酶(AST)、总胆红素(TBil)水平比较,差异均无统计学意义(P>0.05)。术后第3天,2组ALT、AST、TBil水平较术前明显升高,术后第7、14、28天逐渐下降,且不同时间点组内比较差异有统计学意义(P<0.05)。观察组在术后第3、7、14、28天ALT水平均低于对照组(P<0.05),术后第7、14天AST水平低于对照组(P<0.05),术后第3、7、14天TBil水平低于对照组(P<0.05)。观察组肝区疼痛、恶心呕吐、发热、乏力、纳呆的发生率明显低于对照组,差异均有统计学意义(P<0.05)。结论:膈下逐瘀汤能够保护TACE术后患者肝功能,降低术后不良反应,提高中晚期肝癌患者生活质量。Objective: To observe the improving effect of Gexia Zhuyu tang on the liver function damage and clinical adverse reactions of advanced liver cancer after precise transcatheter arterial chemoembolization(TACE). Methods:A total of60 cases of patients with advanced liver cancer and in accordance with the inclusion criteria were divided into the observation group and the control group according to the random number table method,30 cases in each group. After precise TACE,the control group was given western medicine for liver protection,and the observation group was additionally treated with oral administration with Gexia Zhuyu tang based on the treatment of the control group. After treatment,the indexes of the liver function and incidence of adverse reactions in the two groups were observed. Results: Before treatment, compared the levels of alanine aminotransferase(ALT), aspartate aminotransferase(AST) and total bilirubin(TBil) in the two groups, there was no significance in the difference(P>0.05). On the 3rd day after operation, the levels of ALT, AST and TBil in the two groups were significantly increased when compared with those before operation,and were gradually decreased on the 7th,14th and 28th day after operation;the comparison of the two levels in each group at different time points show significance in the difference(P<0.05). On the 3rd,7th,14 th,28 th day after operation,the levels of ALT in the observation group were all lower than those in the control group(P<0.05);on the 7th and 14th day after operation,the levels of AST in the observation group were lower than those in the control group(P<0.05);on the 3rd,7th and 14th day after operation,the levels of TBil in the observation group were lower than those in the control group respectively(P<0.05). The incidence of pain in the liver region,nausea and vomiting,fever,hypodynamia and anorexia in the observation group was significantly lower than that in the control group, differences being significant(P<0.05). Conclusion: Gexia Zhuyu tang can protect the liver

关 键 词：肝癌 膈下逐瘀汤 动脉化疗栓塞术 肝功能 丙氨酸氨基转移酶 草氨酸氨基转移酶 总胆红素 

分 类 号：R735.7[医药卫生—肿瘤]